PREVENTION OF VENOUS THROMBOEMBOLISM IN GYNECOLOGIC SURGERY

  • Maja Pakiž Department of gynecologic in breast oncology, University medical centre Maribor
  • Tina Bizjak Division for gynecology and perinatology, University medical centre Maribor
  • Nina Vene Department for vascular diseases, Division for internal medicine, University medical centre Ljubljana
  • Bojana Bizjak Centre for transfusion medicine, University medical centre Maribor
Keywords: venous thromboembolism, prevention, gynecological surgery, recommendation, antithrombotic drugs

Abstract

Venous thromboembolism (deep vein thrombosis, pulmonary embolism) are serious, but highly preventable complications associated with gynecologic surgery. Risk of thromboembolic complications depends on patient characteristics, type and duration of surgery. Beside adequate hydration, according to the risk stratification we recommend thromboprophlaxis with mechanical methods and antithrombotic drugs (usually low molecular weight heparins). In this article current guidelines for effective and safe thromboprophlaxis for gynecological surgery are presented.

Downloads

Download data is not yet available.

References

Geerts WH, Bergqvist D, Pineo GR, Heit JA, Samama CM, Lassen MR, et al. Prevention of venous thromboembolism: American College of Chest Physicians evidence-based clinical practice guidelines (8th Edition). Chest 2008; 133: 381–453.

Walsh JJ, Bonnar J, Wright FW. A study of pulmonary embolism and deep vein thrombosis after major gynaecological surgery using labelled fibrinogen-phlebography and lung scanning. J obstet Gynecol Br Commonw 1975;81:311–6.

Crandon AJ, Koutts J. Incidence of post-operative thrombosis in gynaecological oncology. Aust N Z J Obstet Gynaecol 1983;23:216–9.

Clarke-Pearson DL, Synan IS, Creasman WT. Significant venous thromboembolism caused by pelvic lymphocysts: diagnosis and management. Gynecol Oncol 1982;131:13136–43.

Martino MA, Borges E, Williamson E, Siegfried S, Cantor AB, Lancaster J, et al. Pulmonary embolism after major abdominal surgery in gynecologic oncology. Obstet Gynecol 2006;107:666–71.

NICE clinical guideline 92: Venous thromboembolism: reducing the risk. Dosegljivo na http://guidance.nice.org.uk/CG92/NICEGuidance/pdf/English (16.10.2012).

Goad KE, Gralnick HR. Coagulation disorders in cancer. Hematol Oncol Clin North Am 1996;10:457–84.

Clarke-Pearson DL, Dodge RK, Synana I, McClelland RC, Maxwell GL. Venous thromboembolism prophylaxis: patients at high risk to fail intermittent pneupatic compression. Obstet Gynecol 2003;101:157–63.

Vessey M, Mant D, Smith A, Yeates D. Oral contraceptives and venous thromboembolism: findings in a large prospective study. Br Med J (Clin Res Ed) 1986;292:526.

Robinson GE, Burren T, Mackie JJ, Bounds W, Walshe K, Faint R, et al. Changes in haemostasis after stopping the combined contraceptive pill: implications for major surgery. BMJ 1991;302:269–71.

Vene N. Hormonsko nadomestno zdravljenje in venski trombembolizmi; Zdrav Vestn 2008; 77: III-39–42.

Cushman M, Kuller LH, Prentice R, Rodabough RJ, Psaty BM, Stafford RS, et al. Estrogen plus progestin and risk of venous thrombosis. JAMA 2004;292:1573–80.

Clarke-Pearson DL, et al. Prevention of Venous Thromboembolic Events After Gynecologic Surgery. Obstet Gynecol 2012;119:155–67.

Gould MK, Garcia DA, Wren SM, Karanicolas PJ, Arcelus JI, Heit JA et al. Prevention of VTE in Nonorthopedic Surgical Patients. Antithrombotic therapy and prevention of thrombosis, 9th ed:ACCP guidelines. Chest 2012;141(2 Suppl):s227S-77.

Ageno W, Manfredi E, Dentali F, Silingardi M, Ghezzi F, Camporese G, et al. The incidence of venous thromboembolism following gynecologic laparoscopy: a multicenter, prospective cohort study. J Thromb Haemost 2006;5:503–6.

Johnston K, Rosen D, Cario G, Chou D, Carlton M, Cooper M, et al. Major complications arising from 1265 operative laparoscopic cases: a prospective review from a single center. J Minim invasive Gynecol 2007;14:339–44.

Ritch JMB, Kim JH, Lewin SN, Burke WM, Sun X, Hercog TJ, et al. Venous thromboembolism and use of prophylaxsis among women undergoing laparoscopic hysterectomy. Obstet Gynecol 2011;117:1367–74.

Walker JL, Piedmonte MR, Spirtos NM, Eisenkop SM, Schlaerth JB, Mannel RS, et al. Laparoscopy compared with laparotomy for comprehensive surgical staging of uterine cancer: Gynecologic Oncology Group Study LAP2. J Clin Oncol 2009;27:5331–6.

Sandadi S, Lee S, Walter A, Gardner GJ, Abu-Rustum NR, Sonoda Y, Brown CL, Jewell E, Parameswaran R, Barakat RR, Leitao MM Jr. Incidence of venous thromboembolism after minimally invasive surgery in patients with newly diagnosed endometrial cancer. Obstet Gynecol. 2012 Nov;120:1077–83.

Kumar S, Al-Wahab Z, Sarangi S, Woelk J, Morris R, Munkarah A, et al. Risk of postoperative venous thromboembolism after minimally invasive surgery for endometrial and cervical cancer is low: A multi-institutional study. Gynecol Oncol. 2013; 130:207-12.

Nicolaides AN, Fareed J, Kakkar AK, Bredin HK, et al. Prevention and treatment of venous thromboembolism. Intrenational Consensus Statement (Guidelines according to scientific evidence). International Angiology 2006;25:101–61.

Turner GM, Cole SE, Brooks JH. The efficacy of graduated compression stockings in the prevention of deep vein thrombosis after major gynaecological surgery. Br J obstet Gynaecol 1984;91:588–91.

Sajid MS, Tai NRM, Goli G, Morris RW, Baker DM, Hamilton G. Knee versus thigh lenght graduated compression stockings for prevention of deep venous thrombosis: a systematic review. Eur J Vasc Endovasc Surg 2006;32:730–6.

Clagett GP, Reisch JS. Prevention of venous thromboembolism in general surgical patients. Results of meta-analysis. Ann Surg 1988;208:227–4.

Oates-Whitehead RM, D'Angelo A, Mol B. Anticoagulant and aspirin prophylaxis for preventing thromboembolism after major gyneacological surgery. Cochrane Database Syst Rev. 2007;(4):CD003679.

Einstein MH, Pritts EA, Hartenbach EM. Venous thromboembolism prevention in gynecologic cancer surgery: a systematic review. Gynecol Oncol 2007;105:813–9.

Ponikvar M, Vene N, Mavri A, Boc A, Fokter SK. Preprečevanje venske trombembolije pri artroplastiki kolka in kolena. Zdrav Vestn 2010;79: 235–243.

Hull RD, Pineo GF, Stein PD, Mah AF, MacIsaac SM, et al. Timing of inital administration of low-molecular-weight heparin prophylaxis against deep vein thrombosis in patients following elective hip arthroplasty: a systematic review. Arch Intern Med 2001;161:1952–60.

Lyman GH, Khorana AA, Kuderer NM, Lee YA, Arcelus JI, Balaban EP. Venous Thromboembolism Prophylaxis and Treatment in Patients With Cancer: American Society of Clinical Oncology Clinical Practice Guidelin Update. J Clin Oncol 2013; 31:2189-2204

Peedicayil A, Weaver A, Li X, Carey E, Cliby W, Mariani A. Incidence and timing of venous thromboembolism after surgery for gynecological cancer. Gynecol oncol 2011;121:64–9.

Rasmussen MS, Jorgensen LN, Willie-Jorgensen P. Prolonged thromboprophylaxis with low molecular weight heparin for abdominal or pelvis surgery. Cochrane Database Syst Rev. 2009;(1):CD004318.

Warkentin TE, Greinacher A. Heparin-induced thrombocytopenia: recognition, treatment, and prevention: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 2004;126(suppl):s311 – 37.

Published
2015-12-14
How to Cite
1.
Pakiž M, Bizjak T, Vene N, Bizjak B. PREVENTION OF VENOUS THROMBOEMBOLISM IN GYNECOLOGIC SURGERY. TEST ZdravVestn [Internet]. 14Dec.2015 [cited 27Apr.2024];84(11). Available from: http://vestnik-dev.szd.si/index.php/ZdravVest/article/view/1268
Section
Review