Pancreas transplantation
Abstract
The transplantation of the pancreas replaces endocrine function of the pancreas, establish normoglycemia, prevents the progression of chronic diabetic complications and prolongs patients life. The most common indication for transplantation is type 1 diabetes with renal failure, in which the transplantation of both organs is performed simultaneously (around 72% of all transplants) or transplantation of the pancreas in patient that already had a kidney transplant. In recent years pancreas is transplanted also in selected patients with type 2 diabetes mellitus (about 7% of the transplants). Pancreas only transplant performed before renal failure is due to narrow indications very rare procedure. Possible complications of transplantation are pancreatic vein or artery thrombosis, intra-abdominal infections, pancreatitis, pancreatic pseudocyst or fistula resulting in the 25-50% of re-laparatomy. With modern immunosuppression, the survival of pancreas transplant markedly improved; 5 year survival in simultaneous kidney and pancreas is around 70%. Even taking into account the possible complications, most authors agree that the simultaneous transplantation of the pancreas and kidney in addition to prolonging life expectancy also significantly improves the quality of patients life.Downloads
References
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