Electrochemotherapy – An effective method for treatment of tumors with combination of chemotherapeutic agent and electric field

  • Tina Stepišnik University of Ljubljana, Faculty of Electrical Engineering
  • Tomaž Jarm University of Ljubljana, Faculty of Electrical Engineering
  • Aleš Grošelj Department of Otorhinolaryngology and cervicofacial surgery, University Medical Centre Ljubljana, Slovenia
  • Ibrahim Edhemović Institute of Oncology Ljubljana, Ljubljana, Slovenia
  • Mihajlo Djokić Clinical Department of Abdominal Surgery, University Medical Centre Ljubljana, Ljubljana, Slovenia
  • Arpad Ivanecz Department of General and Abdominal Surgery, University Medical Centre Maribor, Maribor, Slovenia
  • Blaž Trotovšek Clinical Department of Abdominal Surgery, University Medical Centre Ljubljana, Ljubljana, Slovenia
  • Erik Brecelj The Institute of Oncology Ljubljana, Ljubljana, Slovenia
  • Stojan Potrč Department of General and Abdominal Surgery, University Medical Centre Maribor, Maribor, Slovenia
  • Maja Čemažar The Institute of Oncology Ljubljana, Ljubljana, Slovenia
  • Nebojša Glumac The Institute of Oncology Ljubljana, Ljubljana, Slovenia
  • Tjaša Pečnik The Institute of Oncology Ljubljana, Ljubljana, Slovenia
  • Biserka Veberič Department of Otorhinolaryngology and cervicofacial surgery, University Medical Centre Ljubljana, Slovenia
  • Eldar Gadžijev The Institute of Oncology Ljubljana, Ljubljana, Slovenia
  • Primož Strojan The Institute of Oncology Ljubljana, Ljubljana, Slovenia
  • Marko Snoj The Institute of Oncology Ljubljana, Ljubljana, Slovenia
  • Damijan Miklavčič University of Ljubljana, Faculty of Electrical Engineering
  • Gregor Serša The Institute of Oncology Ljubljana, Ljubljana, Slovenia
DOI: https://doi.org/10.6016/ZdravVestn.1453
Keywords: electrochemotherapy, electroporation, chemotherapeutic agent, tumor, cancer treatment

Abstract

Electrochemotherapy is a local treatment for skin tumors and also deep seated tumors and metastases. Electrochemotherapy is based on enhanced cytotoxic effectiveness of bleomycin or cisplatin by electroporation, which increases drug delivery into cells in tumors. Electrochemotherapy is an ablative technique of high effectiveness with over 80% objective responses of electrochemotherapy treated tumors. Its advantage is the simplicity of the procedure that can be utilized in treatment of different tumor histiotypes. Currently it is predominantly used in palliative intent when the other treatment options have been exhausted. For the translation of electrochemotherapy into the clinics also the technological development that is now focusing into the treatment of deep-seated tumors was important. In Slovenia we are at the forefront in the treatment of liver tumors and head and neck tumors, while the others are developing electrochemotherapy for treatment of bone and brain metastases as well as endoluminal tumors.

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Published
2016-02-20
How to Cite
1.
Stepišnik T, Jarm T, Grošelj A, Edhemović I, Djokić M, Ivanecz A, Trotovšek B, Brecelj E, Potrč S, Čemažar M, Glumac N, Pečnik T, Veberič B, Gadžijev E, Strojan P, Snoj M, Miklavčič D, Serša G. Electrochemotherapy – An effective method for treatment of tumors with combination of chemotherapeutic agent and electric field. TEST ZdravVestn [Internet]. 20Feb.2016 [cited 4May2024];85(1). Available from: http://vestnik-dev.szd.si/index.php/ZdravVest/article/view/1453
Issue
Vol 85 No 1 (2016): January
Section
Review


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