Automatic computerized measurement of retinal blood vessels with adaptive tracking algorithm and association with blood pressure
Abstract
Background: To validate an automatic computer-based method for measuring the caliber of retinal blood vessels and use it to determine the effects of arterial hypertension on the calibers of these vessels and on their ratio.
Methods: 295 patients with increased blood pressure were analyzed. All arterioles and venules located in the area between one half and one disc diameter from the optic disc margin were measured with the computer based program. These measurements were combined to provide the average diameters of retinal arterioles and venules and the association with blood pressure was analyzed. The arteriole-to-venule ratio (AVR) was also calculated.
Results: The average arteriolar diameter of patients who had hypertension from 5 to 15 years was 89.311 μm. Patients with hypertension for more than 15 years they had value of 79.276 μm. Average venular diameters were very similar in both groups (103.319 μm vs. 101.392 μm). We noticed differences in average arteriolar diameter between control group and hypertonic patients who had hypertension for more than 15 years (92.083 μm vs. 79.276 μm). Venular differences were minimal. The average of retinal venules in control group was 106.029 μm, in patients with hypertension for more than 15 years it was 101.392 μm.
Conclusions: Using a computer-assisted method to measure retinal vessel diameter we found out that the diameter of retinal arterioles narrowed with blood pressure level. Our findings demonstrate a relation between presence and severity of hypertension and retinal diameter. Diameter of retinal venules hardly changed. Such relationship was similar with men and women. Fully automated system for analyzing retinal vessels is simple to use, quick and reliable.
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References
Wong TY, Klein R, Klein BE, Tielsch JM, Hubbard L, Nieto FJ. Retinal microvascular abnormalities and their relations with hypertension, cardiovascular diseases and mortality. Surv Ophthalmol 2001; 46: 59–80.
Wong TY, Klein R, Sharrett AR, Duncan BB, Couper DJ, Tielsch JM, et al. Retinal arteriolar narrowing and incident coronary heart disease in men and women: The arteriosclerosis risk in the communities study. JAMA 2002; 287: 1153–9.
Fuchs FD, Maestri MK, Bredemeier M. A study of usefulness of optic fundi examination of hypertensive patients in a clinical setting. J Hum Hypertens 1995; 9: 547–51.
Dimmitt SB, West JN, Eames SM. Usefulness of ophthalmoscopy in mild to moderate hypertension. Lancet 1989; 1: 1103–6.
Attebo K, Mitchell P, Smith W. Visual acuity and the causes of visual loss in Australia: The Blue Mountains Eye Study. Ophthalmology 1996; 103: 357–64.
Scheie HG. Evaluation of ophthalmoscopic changes of hypertension and arteriolar sclerosis. Arch Ophthalmol 1953; 49: 117–38.
Sharrett AR, Hubbard LD, Cooper LS, Sorlie PD, Brothers RJ, Nieto FJ, et al. Retinal arteriolar diameters and elevated blood pressure: The atherosclerosis risk in communities study. Am J Epidemiol 1999; 150: 263–70.
Klein R, Klein BE, Moss SE. The relation of sistemic hypertension to changes in the retinal vasculature: the Beaver Dam eye study. Trans Am Ophthalmol Soc 1997; 95: 329–48.
Wong TY, Hubbard LD, Klein R, Marino EK, Kronmal R, Sharrett AR, et al. Retinal microvascular abnormalities and blood pressure in older people: The cardiovascular health study. Br J Ophthalmol 2002; 86: 1007–13.
Klein R, Klein BE, Moss SE, Wang Q. Hypertension and retinopathy, arteriolar narrowing and arteriovenous nicking in a population. Arch Ophthalmol 1994; 112: 92–8.
Wang JJ, Mitchell P, Leung H, Rochtchina E, Wong TY, Klein R. Hypertensive retinal vessel wall signs in a general older population. Hypertension 2003; 42: 534–45.
Leung H, Wang JJ, Rochtchina E, Tan AG, Wong TY, Hubbard LD, et al. Computer assisted retinal vessel measurement in an older population: correlation between right and left eyes. Clin Experiment Ophthalmol 2003; 31: 326–30.
Leung H, Wang JJ, Rochchina E, Tan AG, Wong TY, Klein R, et al. Relationship between age, blood pressure and retinal vessel diameters in an older population. Inv Ophthalmol Res Vis Ophthalmol 2003; 44: 2900–4.
Adamič Š. Temelji biostatistike. 2. izd. Ljubljana: Medicinska fakulteta univerze v Ljubljani; 1985.
Curk T, Zupan B, Vidmar G. Razvrščanje profilov izražanja genov s strojnim učenjem. Infor Med Slov 2003; 8: 69–80.
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