EPITHELIAL HYPERPLASTIC LARYNGEAL LESIONS: AN OVERVIEW OF RESEARCH WORK IN SLOVENIA AND FURTHER PROSPECTS DEDICATED TO THE MEMORY OF PROFESSOR VINKO KAMBIČ
Abstract
The article, dedicated to the memory of Professor Vinko Kambič, provides a review of research work on epithelial hyperplastic laryngeal lesions (EHLL) in Slovenia. It is largely thanks to Professor Kambič, who recognized the importance of these challenging problems in laryngology more than three decades ago and studied them systematically throughout his long professional career. His views on etiology, histomorphologic classification with terminological problems and modalities of treatment of EHLL, have been published worldwide, internationally accepted and supported by the European Society of Pathology.
Among his greatest achievements, an original histologic grading system of EHLL, the Kambič-Lenart classification, has to be highlighted. The classification, which was further supplemented by the members of the Working group on EHLL of the European Society of Pathology in 1997 and renamed the Ljubljana classification, was devised to cater to specific laryngeal issues. This grading system has been found to be more precise for daily diagnostic work than other classifications and provides data closely correlated to the biological behaviour of the lesions. The results confirm that the central focus of the Ljubljana classification is atypical (or risky) epithelium. For practical purposes, the Ljubljana classification has been based solely on pathohistological criteria of traditional light microscopy. However, for diagnostically difficult cases and when the biological behaviour of recurrent precancerous lesions is to be assessed, additional sophisticated techniques can be of help. Professor Kambič’s team of collaborators owes him a debt of sincere thanks for his long years of teaching, watchful guidance of scientific work, and sincere friendship. With the deepest sense of appreciation for what Professor Kambič did for the development, progress and international recognition of the entire research work of EHLL in Slovenia, we will certainly continue to follow his scientific guidance and his visions of the future.
It is hoped that we will make further contributions to the continuing discussions on the pathogenesis and grading of EHLL, based on the future findings of molecular pathology, and that these discoveries will eventually lead to the worldwide acceptance of the Ljubljana classification grading system.
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References
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