FROM MICROLARYNGOSCOPY TO FLUORESCENCE LARYNGEAL ENDOSCOPY
Abstract
Tissue fluorescence induced by a specific wavelength without photodynamic markers offers new possibilities for the detection and localization of early laryngeal carcinoma. The recognition of cancer is possible with a specially designed system (LIFE, Xillix Co., Richmond, Canada) that displays different fluorescent properties of normal and cancerous tissues on a video monitor. 108 patients (in 74 of whom malignancy was suspected) were included in the study. The laryngoscopic appearance obtained by microlaryngoscopy was compared to the fluorescence image and the pathohistological findings of the observed sites. The results of the study show that detection of laryngeal malignancies with fluorescence laryngoscopy is more effective than with standard microlaryngoscopy and that recognition is even more successful if the two methods are used in combination.
Downloads
References
Kambič V, Varšek M. Nova pota zgodnje diagnostike laringalnih sprememb. Zdrav vestn 1965; 34: 56–7.
Kambič V. Mikrolaringoskopija, njen pomen in indikacije. Med Razgl 1968; 2-3: 233–44.
Kleinsasser O. Microlaryngoscopy. In: Tumors of the larynx and hypopharynx. Stuttgart, Thieme 1988; 155–254.
Strong MS. Diagnosis of carcinoma of the larynx: a review of current methods. Laryngoscope 1975; 3: 516–21.
Epstein JB, Oakley C, Millner A, Emerton S, van der Meij E, Le N. The utility of toluidine blue application as a diagnostic aid in patients previously treated for upper oropharyngeal carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1997; 5: 537–47.
Chisholm EM, Williams SR, Leung JW, Chung SC, Van Hasselt CA, Li AK. Lugol’s iodine dye-enhanced endoscopy in patients with cancer of the esophagus and head and neck. Eur J Surg Oncol 1992; 6: 550–2.
Nauta JM, Leengoed HLLM, Starr WM, Roodenburg JLN, Witjes MJH, Vermey A. Photodynamic therapy of oral cancer. A review of basic mechanisms and clinical applications. Eur J Oral Sci 1996; 104: 69–81.
Kambič V, Gale N. Epithelial hyperplastic lesions of the larynx. Amsterdam Lausanne New York: Elsevier, 1995: 108–8.
Policard A. Étude sur les aspects offerts par des tumeurs expérimentales examinées a la lumière de Wood. Compte–rendue Soc Biol 1924; 91: 1423–4.
Alfano R, Tata D, Cordero J et al. Laser induced fluorescence spectroscopy from native cancerous and normal tissue. IEEE J Quantum Electron 1984; 20: 1507–11.
Ingrams DR, Dhingra JK, Roy K et al. Autofluorescence characteristics of oral mucosa. Head Neck 1997; 1: 27–32.
Hung J, Lam S, LeRiche JC. Autofluorescence of normal and malignant bronchial tissue. Lasers Surg Med 1991; 11: 99–105.
Ghisla S, Massey V, Lhotse JM, Mayhew SG. Fluorescence characteristics of reduced flavins and flavoproteins. In: Yagi K ed. Reactivity of flavins. Tokyo: University of Tokyo Press, 1975: 15–24.
Betz V, Schneckenburger H, Alleroder HP et al. Evaluation of changes in the NADH level between carcinogenic and normal tissue samples by use of fluorescence spectroscopy. Proc SPIE 1994; 2324: 284–91.
Qu J, MacAulay C, Lam S, Palčič B. Optical properties of normal and carcinoma bronchial tissue. Appl Optics 1994; 33: 7397–405.
Palčič B, Lam S, Hung J, MacAulay C. Detection and localization of early lung cancer by imaging techniques. Chest 1991; 99: 742–3.
Lam S, MacAulay C, Hung J. Detection of dysplasia and carcinoma in situ using a lung imaging fluorescence endoscope (LIFE) device. J Thorac Cardiovasc Surg 1993; 105: 1035–40.
Lam S, Hung J, Palčič B. Mechanism of detection of early lung cancer by ratio fluorometry. Lasers Life Sci 1991; 4: 67–73.
Hellquist H, Cardesa A, Gale N, Kambič V, Michaels L. Criteria for grading in the Ljubljana classification of epithelial hyperplastic laryngeal lesions. A study by members of the Working group on epithelial hyperplastic laryngeal lesions of the European Society of Pathology. Histopathology 1999; 34: 226–35.
Malzahn K, Dreyer T, Glanz H, Arens C. Autofluorescence endoscopy in the diagnosis of early laryngeal cancer and its precursor lesions. Laryngoscope 2002; 112: 448–93.
Harris DM, Werkhaven J. Endogenous porphyrin fluorescence in tumors. Lasers Surg Med 1987; 7: 467–72.
The Author transfers to the Publisher (Zdravniški vestnik/Slovenian Medical Journal) all economic copyrights following form Article 22 of the Slovene Copyright and Related Rights Act (ZASP), including the right of reproduction, the right of distribution, the rental right, the right of public performance, the right of public transmission, the right of public communication by means of phonograms and videograms, the right of public presentation, the right of broadcasting, the right of rebroadcasting, the right of secondary broadcasting, the right of communication to the public, the right of transformation, the right of audiovisual adaptation and all other rights of the author according to ZASP.
The aforementioned rights are transferred non-exclusively, for an unlimited number of editions, for the term of the statutory
The Author can make use of his work himself or transfer subjective rights to others only after 3 months from date of first publishing in the journal Zdravniški vestnik/Slovenian Medical Journal.
The Publisher (Zdravniški vestnik/Slovenian Medical Journal) has the right to transfer the rights, acquired parties without explicit consent of the Author.
The Author consents that the Article be published under the Creative Commons BY-NC 4.0 (attribution-non-commercial) or comparable licence.
