EPITHELIAL HYPERPLASTIC LESIONS IN CHRONIC HYPERPLASTIC LARYNGITIS OF PATIENTS TREATED FROM 1994 TO 1998 AT THE DEPARTMENT OF OTORINOLARYNGOLOGY AND CERVICOFACIAL SURGERY IN LJUBLJANA
Abstract
Different grades of epithelial hyperplastic lesions can be found in various pathological entities, e.g. chronic laryngitis, polyps, nodules, Renike’s edema, papillomas, and cysts. Among all these entities, atypical hypeplasia or risky epithelium occurs most frequently in chronic hyperplastic laryngitis. Malignant transformation develops almost exclusively in this type of aberration. The aim of this study was to determine the main ethiologic agents and to evaluate the frequency of histomorphlogic epithelial changes, the male – female ratio, age and sex distribution of patients with a diagnosis of chronic laryngitis from the Ljubljana region treated in the period from 1994 to 1998 at the Department Otorhinolaryngology and Cervicofacial Surgery, Clinical Centre, Ljubljana. A retrospective clinical pathological analysis was performed on a series of 178 patients with 239 biopsies. The laryngeal biopsies were classified according to the Ljubljana classification. According to the degree of epithelial lesions, a histologic diagnosis of atypical hyperplasia (risky epithelium) was established in 8.1% of cases. The patients’ ages ranged from 21 to 89 years. The highest frequency of chronic laryngitis was in females between 40 and 49, and in male patients between 50 and 59 years. The male – female ratio was 8 : 1. We found that 79% of patients diagnosed with chronic laryngitis were smokers and 31% alcoholics. Nearly half (48%) of patients were employed in industry.
There is a need for long term follow-up observation to obtain a reliable percentage of malignant transformations in atypical hyperplasia in our series. Cognition that atypical hyperplasia may transform into cancer requires that increasing attention is paid to early detection and adequate treatment.
Downloads
References
Kambič V. Epithelial hyperplastic lesions - a challenging topic in laryngology. Acta Otolaryngol (Stockh) 1997: Suppl 527: 7-11.
Kambič V, Gale N. Laryngeal epithelial hyperplastic lesions, Amsterdam: Elsevier, 1995: 1-265.
Kleinsasser O. šber die verschiedenen Formen der Plattenepithelhyperplasien im Kehlkopf und ihre Beziehungen zum Carcinom. Archiv Ohren-usw Heil-u Z Hals-usw Heilk 1959; 174: 290-313.
Kleinsasser O. Die Klassifikation und Differentialdiagnose der Epithelhiperplasien der Kehlkopfschleimhaut auf Grund histomorphologischer Merkmale. Z Laryng Rhinol 1963; 42: 339-62.
Kambič V, Lenart I. Notre classification des hyperplasies de l'epithelium du larynx au point de vu pronostic. JFORL 1971; 20: 1145-50.
Michaels L. The Kambič-Gale method of assessment of epithelial hyperplastic lesions of the larynx in comparison with the dysplasia grade method. Acta Otolaryngol (Stockh) 1997; Suppl 527: 17-20.
Burkhardt A. Morphological assessment of malignant potential of epithelial hyperplastic lesions. Acta Otolaryngol (Stockh) 1997; Suppl 527: 12-16.
Hellquist H, Cordesa A, Gale N, Kambič V, Michaels L. Criteria for gradnig in the Ljubljana Classification of epithelial hyperplastic laryngeal lesions. A study by members of the Working Group on epithelial hyperplastic laryngeal lesions of the European Society of pathology. Histopatology 1999; 34: 226-233.
Gale N, Kambič V, Michaels L et al. The Ljubljana classification: a practical strategy for the diagnosis of laryngeal precancerous lesions. Advances in Anatomic Pathology 2000; 7: 240-50.
Fiorella R, Di Nicola V, Resta L. Epidemiological and clinical relief on hyperplastic lesions of the larynx. Acta Otolaryngol (Stockh) 1997; Suppl 527: 77-81.
Wynder EL. Toward the prevention of laryngeal cancer. Laryngoscope 1975; 85: 1190-6.
Gabriel CE, Jones DG. The importance of chronic laryngitis. J Laryngol Otol 1960; 74: 349-57.
Glanz H, Kleinsasser O. Chronische laryngitis und carcinom. Arch Oto-Rhino-Laryng 1976; 212: 57-75.
Cancer Registry of Slovenia, Institute of Oncology. Ljubljana 1994-1998, Reports No 33-37.
Gale N, Zidar N, Fischinger J, Kambič V. Clinical applicability of the Ljubljana classification of epithelial hyperplastic laryngeal lesions. Clin Otolaryngol 2000; 25: 227-32.
The Author transfers to the Publisher (Zdravniški vestnik/Slovenian Medical Journal) all economic copyrights following form Article 22 of the Slovene Copyright and Related Rights Act (ZASP), including the right of reproduction, the right of distribution, the rental right, the right of public performance, the right of public transmission, the right of public communication by means of phonograms and videograms, the right of public presentation, the right of broadcasting, the right of rebroadcasting, the right of secondary broadcasting, the right of communication to the public, the right of transformation, the right of audiovisual adaptation and all other rights of the author according to ZASP.
The aforementioned rights are transferred non-exclusively, for an unlimited number of editions, for the term of the statutory
The Author can make use of his work himself or transfer subjective rights to others only after 3 months from date of first publishing in the journal Zdravniški vestnik/Slovenian Medical Journal.
The Publisher (Zdravniški vestnik/Slovenian Medical Journal) has the right to transfer the rights, acquired parties without explicit consent of the Author.
The Author consents that the Article be published under the Creative Commons BY-NC 4.0 (attribution-non-commercial) or comparable licence.
