HORMONE REPLACEMENT THERAPY AND CANCER
Abstract
Background. Sex steroids are not known to damage DNA directly. They can stimulate or inhibit cell proliferation, and thus can modulate tumor developmental progression.
Results. Sex steroids-related tumors in women are represented by breast cancer and endometrial cancer, and a possible relationship exists between sex steroids and both ovarian and colon cancer. Among current ERT users or those who stopped use 1–4 years previously, the relative risk of having breast cancer diagnosed is low, increases by factor of 1.023 for each year of hormone use. An appropriate combination of estrogen and progestin does not appear to increase, and may even decrease, the risk of endometrial cancer. Studies on HRT and risk of epithelial ovarian cancer have produced conflicting results but most data seem to exclude a strong assotiation. It is important that available data suggest a reduced risk of benign colorectal adenoma and colon cancer for 30–40%.
Conclusions. After breast cancer, endometrial cancer, melanoma or epithelial ovarian cancer HRT is not absolute contraindication. Low-grade endometrial stromal sarcoma should be considered to be a contraindication to HRT.
Downloads
References
Genazzani AR, Gaducci A, Gambacciani M. Hormone replacement therapy and cancer. Climacteric 2001; 4: 181–93.
Kenemans P. Tissue specifity of sex hormones and so-called modulation of receptors and anzymes. Maturitas 2001; 37: 145–6.
Marconcini L, Marchio S, Morbidelli L et al. C-fos-induced growth factor/ vascular endothelial factor D induces angiogenesis in vivo and in vitro. Proc Natl Acad Sci USA 1999; 96: 9671–6.
Incidenca raka v Sloveniji 2000. Ljubljana: Onkološki inštitut – Register raka za Slovenijo, 2003.
Marsden J. Hormone replacement therapy and breast cancer. Maturitas 2000; 34: S11–S24.
Chetrite GS, Pasqualini JR. The selective estrogen enzyme modulator (SEEM) in breast cancer. J Steroid Biochem Mol Biol 2001; 76: 95–104.
Schneider HPG. HRT ans cancer risks. Maturitas 2002; 43: S35–S52.
Collaborative Group on Hormonal Factors in Breast Cancer. Breast cancer and hormone replacement therapy: collaborative reanalysis of data from 51 epidemiological studies of 52 705 women with breast cancer and 108 411 women without breast cancer. Lancet. 1997; 350.
Bilimoria MM, Winchester DJ, Sener SF, Motykie G, Sehgal UL, Winchester DP. Estrogen replacement therapy and breast cancer: analysis of age of onset and tumour characteristics. Ann Surg Oncol 1999; 6: 200–7.
Schairer C, Gail M, Byrne C, Rosenberg PS, Sturgeon SR, Brinton LA, Hoover RN. Estrogen replacement therapy and breast cancer. J Natl Cancer Inst 1999; 91: 264–70.
Mortimer JE. Hormone replacement therapy end beyond. The clinical challange of menopausal symptoms in breast cancer survivals. Geriatrics 2002; 57: 25–31.
Cuzick J. Is hormone replacement therapy safe for breast cancer patients? J Natl Cancer Inst 2001; 93: 733–4.
Pritchard KI, Khan H, Levine M. Clinical practice guidelines for the care and tretment of breast cancer: CMAJ 2002; 166: 1017–22.
Uršič-Vrščaj M, Bebar S. A case-control study of hormone replacement therapy after primary surgical breast cancer treatment. Eur J Surg Oncol 1999: 25; 146–51.
Pike MC et al. Estrogen-progestin raplacement therapy and endometrial cancer. J Nat Ca Inst. 1997; 89: 1110–6.
Creasman WT. HRT in women who have had breast or endometrial cancer. J Epidemiol Biostat 1999; 4: 217–20.
Grodstein F, Martinez ME, Platz EA, Giovannucci E, Colditz GA, Kautzky M, Fuchs C, Stampfer MJ. Postmenopausal hormone use and risk for colorectal cancer and adenoma. Ann Intern Med 1998; 128: 705–12.
Grun CM, Driscoll MS, Grant-Kels JM. The relationship of pregnancy, hormones, and melanoma. Semin Cutan Med Surg 1998; 17: 167–71.
Negri E, Tzonou A, Beral V et al. Hormonal therapy for menopause and ovarian cancer in a collaborative re-analysis of European studies. Int J Cancer 1999; 80: 848–1.
Uršič-Vrščaj M, Bebar S, Primic-Žakelj M. Hormone replacement therapy after invasive ovarian serous cystadenocarcinoma treatment: the effect on survival. Menopause 2001; 8: 70–5.
The Author transfers to the Publisher (Zdravniški vestnik/Slovenian Medical Journal) all economic copyrights following form Article 22 of the Slovene Copyright and Related Rights Act (ZASP), including the right of reproduction, the right of distribution, the rental right, the right of public performance, the right of public transmission, the right of public communication by means of phonograms and videograms, the right of public presentation, the right of broadcasting, the right of rebroadcasting, the right of secondary broadcasting, the right of communication to the public, the right of transformation, the right of audiovisual adaptation and all other rights of the author according to ZASP.
The aforementioned rights are transferred non-exclusively, for an unlimited number of editions, for the term of the statutory
The Author can make use of his work himself or transfer subjective rights to others only after 3 months from date of first publishing in the journal Zdravniški vestnik/Slovenian Medical Journal.
The Publisher (Zdravniški vestnik/Slovenian Medical Journal) has the right to transfer the rights, acquired parties without explicit consent of the Author.
The Author consents that the Article be published under the Creative Commons BY-NC 4.0 (attribution-non-commercial) or comparable licence.