Predictive toxicogenomics for cancer risk assessment
Abstract
Abstract: Every organism, and therefore also humans, is the product of its genes in combination with its environment. The activity of genes is strictly regulated and is continuously liable to changes. The response of an organism to changes in its environment, such as the exposure to a toxic substance, leads to altered gene expressions. Analysing modified gene expression profiles as a result of exposure to chemical substances, can therefore aid to determine the hazardous properties of those substances, such as on carcinogenic capacity. This toxicogenomics approach also provides the possibility to drastically reduce the traditional animal tests.
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References
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