The impact of fraction of exhaled nitric oxide measurements in patients with asthma exacerbation
Abstract
BACKGROUND
Fraction of exhaled nitric oxide measurements (FENO) is accessible, a fast, non- invasive, highly repeatable test for determining eosinophilic airway inflammation.
PURPOSE
The objective of this prospective study is to determine the structure of FENO measurements in patients with asthma exacerbation and characteristics of asthma with FENO as a good indicator of asthma exacerbation.
METHODS
This study included 92 patients with asthma exacerbation, aged from 17 to 83 years. Patients were distributed into 3 groups with respect to FENO range: FENO > 50 ppb, FENO between 25 and 50 ppb , FENO < 25 ppb. Analyses by age, sex, form of asthma, presence of acute respiratory failure (ARF), rhinitis and treatment were conducted. Mean values of FENO, FEV1, PEF, T.I. were calculated. The results with mean FENO, FEV1, PEF, T.I. values were compared between 3 groups: FENO > 50ppb, FENO < 25 ppb and control group of 27 healthy adults. Results: 34 patients (37 % of all) were in FENO > 50 ppb group; 17 females, 17 males. Allergic asthma was found in 19 patients (56 %), 2 patients (6 %) had ARF, asthma with rhinitis was found in 8 patients (24 %). 33 patients (36 % of all) were in the FENO < 25 ppb group; 25 females (76 %), 8 males (24 %). 23 patients (70 %) suffered from nonallergic asthma, ARF was found in 6 patents (18 %), and asthma with rhinitis in 2 patients (6 %). Compared to patients with FENO values higher than 50 ppb, the results showed statistically significantly lower FEV1 and PEF values in patients with FENO < 25 ppb(p < 0.005) and in healthy adults (p = 0.000).
CONCLUSIONS
There are differences in sex, form of asthma, presence of rhinitis, burden of asthma and treatment between patients with FENO > 50 ppb and FENO < 25 ppb.
Downloads
The Author transfers to the Publisher (Zdravniški vestnik/Slovenian Medical Journal) all economic copyrights following form Article 22 of the Slovene Copyright and Related Rights Act (ZASP), including the right of reproduction, the right of distribution, the rental right, the right of public performance, the right of public transmission, the right of public communication by means of phonograms and videograms, the right of public presentation, the right of broadcasting, the right of rebroadcasting, the right of secondary broadcasting, the right of communication to the public, the right of transformation, the right of audiovisual adaptation and all other rights of the author according to ZASP.
The aforementioned rights are transferred non-exclusively, for an unlimited number of editions, for the term of the statutory
The Author can make use of his work himself or transfer subjective rights to others only after 3 months from date of first publishing in the journal Zdravniški vestnik/Slovenian Medical Journal.
The Publisher (Zdravniški vestnik/Slovenian Medical Journal) has the right to transfer the rights, acquired parties without explicit consent of the Author.
The Author consents that the Article be published under the Creative Commons BY-NC 4.0 (attribution-non-commercial) or comparable licence.