Analysis of neurovascular coupling in migraneours
Abstract
Background: According to recent data it is not clear whether neurovascular coupling is disturbed in migraneours during headache free period. The aim of our study was to establish whether the relationship between visually evoked cerebral blood flow responses (VEFR) and visual evoked potentials (VEP) is changed in migraneours during headache free period.
Methods: The records were made from 30 healthy volunteers and 30 migraine patients. The mean arterial velocity in the left middle cerebral artery and the mean arterial velocity in right posterior cerebral artery were monitored by using transcranial Doppler ultrasound. The VEP were recorded from occipital leads. Neuronal activity was changed by changing visual contrast.
Results: We found that significant and moderate relationship between the VEP and the VEFR (r = 0.66; p < 0.01) in healthy subjects and in migraneours as well (r = 0.63; p < 0.01). The difference between the regression slopes of the healthy subjects (b = 0.55) and the patients with migraine (b = 0.88) was significant (p = 0.04).
Conclusions: We concluded that neurovascular coupling in migraneours during headache free period is more active than in healthy subjects.
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References
Hargreaves RJ, Shepheard SL. Pathophysiology of migraine – new insights. Can J Neurol Sci 1999; 26 Suppl 3: S12–9.
Thie A, Fuhlendorf A, Spitzer K, Kunze K. Transcranial Doppler evaluation of common and classic migraine. Part I. Ultrasonic features during the headache – free period. Headache 1990; 30: 201–8.
Backer M, Sander D, Hammes MG, Funke D, Deppe M, Conrad B, Tolle TR. Altered cerebrovascular response pattern in interictal migraine during visual stimulation. Cephalalgia 2000; 21: 611–6.
Baezner H, Steinke W, Daffertshofer M, Hennerici M. Vasoneuronal coupling in migraineurs after subcutaneous sumatriptan: a TCD study. J Neurol Sci 1999; 167: 50–5.
Shibata K, Osawa M, Iwata M. Simultaneous recording of pattern reversal electroretinograms and visual evoked potentials in migraine. Cephalalgia 1997; 17: 742–7.
Shibata K, Osawa M, Iwata M. Pattern reversal visual evoked potentials in migraine with aura and migraine aura without headache. Cephalalgia 1998; 18: 319–23.
Yilmaz M, Bayazit YA, Erbagci I, Pence S. Visual evoked potential changes in migraine. Influence of migraine attack and aura. J Neurol Sci 2001; 184: 139–4.
Yucesan C, Sener O, Mutluer N. Influence of disease duration on visual evoked potentials in migraineurs. Headache 2000; 40: 384–8.
Zaletel M, Strucl M, Rodi Z, Zvan B. The relationship between visually evoked cerebral blood flow velocity responses and visual-evoked potentials. Neuroimage 2004; 22: 1784–9.
Olesen J, Goadsby P, Steiner T. The international classification of headache disorders: 2nd edition. Lancet Neurol 2003; 2: 720.
Harding GF, Odom JV, Spileers W, Spekreijse H. Standard for visual evoked potentials 1995. The International Society for Clinical Electrophysiology of Vision. Vision Res 1996; 36: 3567–72.
Glantz SA. Primer of applied regression and analysis of variance. New York: Mcgraw-Hill; 1998. p 28.
Fumal A, Bohotin V, Vandenheede M, Schoenen J. Transcranial magnetic stimulation in migraine: a review of facts and controversies. Acta Neurol Belg 2003; 103: 144–54.
Battelli L, Black KR, Wray SH. Transcranial magnetic stimulation of visual area V5 in migraine. Neurology 2002; 58: 1066–9.
Mulleners WM, Chronicle EP, Palmer JE, Koehler PJ, Vredeveld JW. Visual cortex excitability in migraine with and without aura. Headache 2001; 41: 565–72.
Ambrosini A, de Noordhout AM, Sandor PS, Schoenen J. Electrophysiological studies in migraine: a comprehensive review of their interest and limitations. Cephalalgia 2003; 23 Suppl 1: 13–31.
Oelkers R, Grosser K, Lang E, Geisslinger G, Kobal G, Brune K, Lotsch J. Electrophysiological studies in migraine: a comprehensive review of their interest and limitations. Cephalalgia 2003; 23 Suppl 1: 13–31.
Shepherd AJ. Increased visual after-effects following pattern adaptation in migraine: a lack of intracortical excitation? Brain 2001; 124: 2310–8.
Judit A, Sandor PS, Schoenen J. Habituation of visual and intensity dependence of auditory evoked cortical potentials tends to normalize just before and during the migraine attack. Cephalalgia 2000; 20: 714–9.
Oelkers R, Grosser K, Lang E, Geisslinger G, Kobal G, Brune K, Lotsch J. Visual evoked potentials in migraine patients: alterations depend on pattern spatial frequency. Brain 1999; 122: 1147–55.
Rosengarten B, Sperner J, Gorgen-Pauly U, Kaps M. Cerebrovascular reactivity in adolescents with migraine and tension-type headache during headache-free interval and attack. Headache 2003; 43: 458–63.
Weiller C, May A, Limmroth V, Juptner M, Kaube H, Schayck RV, Coenen HH, Diener HC. Brain stem activation in spontaneous human migraine attacks. Nat Med 1995; 1: 658–60.
Masuzaki M, Utsunomiya H, Yasumoto S, Mitsudome A. A case of hemiplegic migraine in childhood: transient unilateral hyperperfusion revealed by perfusion MR imaging and MR angiography. AJNR Am J Neuroradiol 2001; 22: 1795–7.
De Benedittis G, Ferrari Da Passano C, Granata G, Lorenzetti A. CBF changes during headache-free periods and spontaneous/induced attacks in migraine with and without aura: a TCD and SPECT comparison study. J Neurosurg Sci 1999; 43: 141–6.
Soriani S, Feggi L, Battistella PA, Arnaldi C, De Carlo L, Stipa S. Interictal and ictal phase study with Tc 99m HMPAO brain SPECT in juvenile migraine with aura. Headache 1997; 37: 31–6.
Spierings EL. Pathogenesis of the migraine attack. Clin J Pain 2003; 19: 255– 62.
Cao Y, Aurora SK, Nagesh V, Patel SC, Welch KM. Functional MRI–BOLD of brainstem structures during visually triggered migraine. Neurology 2002; 59: 72–8.
Tomita Y, Tomita M, Schiszler I, Amano T, Tanahashi N, Kobari M, Takeda H, Ohtomo M, Fukuuchi Y. Repetitive concentric wave-ring spread of oligemia/hyperemia in the sensorimotor cortex accompanying K(+)-induced spreading depression in rats and cats. Neurosci Lett 2002; 322: 157–60.
Neuman RS, Zebrowska G. Serotonin (5–HT2) receptor mediated enhancement of cortical unit activity. Can J Physiol Pharmacol 1992; 70: 1604–9.
Holschneider DP, Scremin OU, Huynh L, Chen K, Seif I, Shih JC. Regional cerebral cortical activation in monoamine oxidase A–deficient mice: differential effects of chronic versus acute elevations in serotonin and norepinephrine. Neuroscience 2000; 101: 869–77.
Tepper SJ, Rapoport AM, Sheftell FD. Mechanisms of action of the 5–HT1B/ 1D receptor agonists. Arch Neurol 2002; 59: 1084–8.
Goadsby PJ, Hoskin KL, Knight YE. Substance P blockade with the potent and centrally acting antagonist GR205171 does not effect central trigeminal activity with superior sagittal sinus stimulation. Neuroscience 1998; 86: 337–43.
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