Cumulative Helicobacter pylori eradication rates in Slovenia in the year 2008

Abstract

Background: h e aim of the study was to examine cumulative Helicobacter pylori eradication rates in Slovenia in the year 2008 that can be achieved in clinical practice by clasic i rst and second regimens suggested by Maastricht recommendations and third line empirical regimens. Methods: We performed cross sectional study that included 500 consecutive patients, who underwent urea breath test at er Helicobacter pylori eradication regimens in AM DC Rogaška in the period from January to September 2008.We analysed eradication rates at er OMC regimen, 7 days (omeprazole, metronidazole, clarithromycin), OAC regimen, 7 days (omeprazole, amoxicillin, clarithromycin), BMTO regimen, 14 days (colloid bismuth subcitrate, metronidazole, oxytetracycline, omeprazole) and OA regimen, 14 days (omeprazole, amoxicillin). Results: Total 308 patients received OMC regimen with eradication rate 78.6 % (95 % CI 76.3%–80.9%). Total 80 patients received OAC regimen with eradication rate 80  % (95 % CI 75.6 %–84.4 %). At er failure of the i rst regimen, they received the opposite i rst-line regimen. In the case of eradication failure, 23 patients received BMTO regimen as a third-line therapy with eradication rate 82.6 % and 14 patients received OA regimen with eradication rate 64.3 %. Nine of 388 patients who started Helicobacter pylori eradication treatment in our study remained positive at er they received all the available therapeutical regimens (2,3 %). Conclusions. Cumulative Helicobacter pylori eradication rate in Slovenia in the year 2008 is still very high–97.7 %. h ese results are comparable with the results in other European countries.