PREVALENCE OF HEPATITIS A IN B AMONG BLOOD DONORS WITH HISTORY OF JAUNDICE
Abstract
Background. Preventing transmission of infectious disease through blood transfusion presents one of the greatest challenges of transfusion medicine. All donations are monitored for syphilis since 1960, hepatitis B (HBsAg) since 1970, aids (anti HIV) since 1986 and hepatitis C (anti-HCV) since 1993.
After introducing a donor questionnaire in 1994, we started to test all donors with a history of hepatitis for anti-HBc, antiHBs antibodies, and antibodies against hepatitis A (anti-HAV).
Methods. Data on donors were found in the Datec computer program which is commonly used in all transfusion institutions in Slovenia.
Results. Among 43,000 registered donors, 764 (1.78%) had a history of hepatitis. After testing, we found 666 of them positive (87.2%) for hepatitis A or B antibodies. 654 (85.6%) donors had hepatitis A antibodies and 98 (12.8%) had anti-HBc antibodies. Among these 98, 30 donors (30.6%) had no anti-HBs antibodies. 86 donors (11%) had antibodies against hepatitis A and B.
Conclusions. After additional testing of donors for hepatitis B antibodies, we excluded 30 (0.069%) HBsAg negative, antiHBc positive and anti-HBs negative donors with history of hepatitis.
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References
Svet Evrope. Izbira dajalcev. Priporočila o pripravi, uporabi in zagotavljanju kakovosti komponent krvi. 9. izdaja. Ljubljana: Zavod RS za transfuzijsko medicino, 2003: 29–49.
Levičnik-Stezinar S, Baraga L, Hrašovec V, Kavaš E, Kramar I, Slokan M, Urlep-Šalinović V, Šunjevarič M. Presejalno testiranje kot ukrep za zagotavljanje varne transfuzije. Zdrav Var 1998; 37: 527–30.
Majcen-Vivod B, Urlep-Šalinović V, Jelatancev B. Prenos hepatitisov B in C s krvjo v triletnem obdobju od 1996 do 1998. Med Razgl 2000; 39: Suppl 5: 3–8.
Mollison PL, Engelfriet CP, Contreras M. Blood transfusion in clinical medicine. 10th ed. Oxford: Blackwell Scientific Publications, 1997: 510–25.
Kann M, Gerlich WH. Hepatitis B. In: Topley and Wilson’s microbiology and microbial infections. 9th ed. Volume 1, Virology. Avon: Bath Press, 1998: 745–73.
Van der Poel CL. Screening for the hepatits viruses. In: Barbara JAJ, Sultsman MK, Rossi U. Proceedings of the ESTM residential course. Pärnu: ESTM, 1998: 7–31.
Walker RH ed. Technical manual of American Association of Blood Banks. 12th ed. Bethesda: American Association of Blood Banks, 1996: 564–6.
Krusius T. Blood donor screening for anti-HBc to prevent transfusion transmitted infection. In: Barbara JAJ, Sultsman MK, Rossi U. Proceedings of the ESTM residential course. Pärnu: ESTM, 1998: 55–61.
Schreiber GB, Busch MP, Kleinman SH, Korelitz JJ. The risk of transfusion transmitted viral infections. N Engl J Med 1996; 334: 1685–90.
Murphy EL, Busch MP, Tong M, Cornett P, Vyas GN. A prospective study of the risk of transfusion-acquired viral infections. Transf Med 1998; 8: 173–8.
Barbara JAJ. Introduction: range of agents and their properties. In: Barbara JAJ, Sultsman MK, Rossi U. Proceedings of the ESTM residential course. Pärnu: ESTM, 1998: 1–3.
Erhard S, Roth WK. Feasibility, efficacy and economy of NAT testing in Germany. In: Plenary state of the art book. VIII European Congress of the International Society of Blood Transfusion. Istanbul: International Society of Blood Transfusion, 2003: 27–8.
Robertson HB, Lemon SM. Hepatitis A and E. In: Collier L, Balows A, Sussman M. Topley and Wilson’s microbiology and microbial infections. 9th ed. Vol. 1 Virology. Avon: Bath Press, 1998: 693–716.
Evarus H. Clinical importance of blood safety. In: Barbara JAJ, Sultsman MK, Rossi U. Proceedings of ESTM residential course. Pärnu: ESTM, 1998: 11–21.
Mannucci PM, Gdovin S, Gringeri A, Colombo M, Mele S. Transmission of hepatitis A to patients with haemophilia by factor VIII concentrate treated with organic solvent and detergent to inactivate viruses. Ann Intern Med 1994; 120: 1–7.
Parkkinen J. Viral inactivation procedures of plasma products. In: Barbara JAJ, Sultsman MK, Rossi U. Proceedings of the ESTM residential course. Pärnu: ESTM, 1998: 187–91.
Allain JP, Hewitt PE, Tedder RS, Williamson LM. Evidence that anti-HBc but not HBV DNA testing may prevent some HBV transmission by transfusion. Br J Hematol 1999; 107: 186–95.
Sato S, Ohhashi W, Ihara H, Sakaya S, Kato T, Ikeda H. Comparison of the sensitivity of NAT using pooled donor samples for HBV and that of a serologic HBsAg assay. Transf Med 2001; 41: 1107–13.
Hiroshi Y et al. Frequent presence of HBV in the sera of HBsAg negative, anti-HBc positive blood donors. Transf Med 2001; 41: 1093–9.
Majcen-Vivod B. Spremljanje prenosa hepatitisov A, B in C s krvjo v SB Maribor v triletnem obdobju od 1996–1998. Specialistična naloga. Maribor: Splošna bolnišnica, 2000: 28–39.
Prodinger WM, Larcher C, Solder BM, Geissler D, Dierich MP. Hepatitis A in Western Austria – the epidemiologic situation before the introduction of active immunisation. Infection 1994; 22: 53–5.
Glaser E. Kri in krvni izdelki skozi lupo zakonskih in drugih predpisov Evropske zveze. Zdrav Vestn 1996; 65: 695–7.
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