PROGRAMME OF ASSISTED REPRODUCTION IN MARIBOR OVER THE PERIOD 1998–2002
Abstract
Background. During the period between 1998 and 2002 Department for reproductive medicine, Maribor Teaching Hospital performed 31.1% of all cycles of assisted reproduction (ART) in Slovenia.
Methods. Three different methods of ART (in vitro fertilization – IVF, intracytoplasmic sperm injection with ejaculated sperm – ICSI and testicular sperm TESA/TESE) were compared. Comparison of clinical results was also made between the period when up to 4 embrios were transferred and the period when up to 2 embrios were transferred.
Results. During the five year period, pregnancy rate per started cycle was between 29.6% in 1998 and 36.4% in 2002. During the whole period, delivery rate per started cycle was higher than the mean average reported for European centers for the year 1999. The observed values were higher with the tendeny to slightly increase from 27.4% in 1998 to 30.8% in 2001.
Conclusions. Clinical results of ART programme at Maribor Clinic for reproductive medicine in the observed five year period over the period 1998–2002 were superior to the last results published by the European register of ART.
Downloads
References
Ogrizek-Pelkič K, Verdenik I. Prezgodnji porod v skupini nosečnic, ki so zanosile po postopkih oploditve z biomedicinsko pomočjo v Sloveniji 1997– 1999. Novakovi dnevi. Ljubljana: Združenje za perinatalno medicino, 2001: 54–5.
Nygren K, Nyboe-Andersen A. Assisted reproductive technology in Europe,1999. Results generated from European registers by ESHRE. Human Reprod 2002; 17: 3260–74.
Meden-Vrtovec H, Klun-Virant I, Tomaževič T et al. Program zunajtelesne oploditve na Ginekološki kliniki v Ljubljani. Zdrav Vestn 2001; 70: 89–95.
Borko E. Razvoj dejavnosti reproduktivne medicine v Mariboru. Zdrav Vestn 2002; 71: Suppl. I: 3–5.
Vlaisavljević V, Kovačič B. Naše prve izkušnje s tehniko direktnega vnosa semenčice v citoplazmo jajčne celice (ICSI) pri zdravljenju moške neplodnosti. Zdrav Vestn 1995; 64: 677–9.
Cederblad M, Friberg B, Ploman F. Intelligence and behaviour in children born after in vitro fertilization treatment. Hum Reprod 1996; 11: 2052–7.
Bonduelle M, Aytoz A, van Assche E, Devroey P. Incidence of chromosomal aberrations in children born after assisted reproduction through intracytoplasmic sperm injection. Hum Reprod 1998; 13: 781–2.
Golombok S, Brewaeys A, Cook R. The European study of assisted reproduction families: family functioning and child development. Hum Reprod 1996; 11: 2324–31.
Keith L, Oleszczuk J, Keith D. Multiple gestation: reflections on epidemiology, causes and consequences. Int J Fertil 2000; 45: 206–14.
Zakon o zdravljenju neplodnosti in postopkih oploditve z biomedicinsko pomočjo (ZZNPOB). Uradni list Republike Slovenije, št. 80, 8. 8. 2000; 8666– 72.
Informacija o stanju na področju oploditve z biomedicinsko pomočjo v Sloveniji. Poročilo o opravljenih postopkih OBMP v Ljubljani, Mariboru in Postojni. Ljubljana: Komisija za OBMP pri Ministrstvu za zdravje Republike Slovenije, 2002.
Vlaisavljević V, Kovačič B, Reljič M, Gavrić-Lovrec V. Three protocols for monitoring of follicle development in 587 unstimulated cycles for IVF and ICSI. J Reprod Med 2001; 46: 892–8.
Vlaisavljević V, Kovačič B, Gavrić-Lovrec V, Reljič M. Simplification of the clinical phase of IVF and ICSI treatment in programmed cycles. Int J Gynecol Obstet 2000; 69: 135–42.
Vlaisavljević V, Kovačič B, Reljič M, Gavrić-Lovrec V, Čižek-Sajko M. Results of intracytoplasmic sperm injection of single oocyte in 362 unstimulated cycles. J Assist Reprod Genetics 2002; 19: 127–31.
Vlaisavljević V, Kovačič B, Reljič M, Gavrić-Lovrec V, Čižek-Sajko M. Results of intracytoplasmic sperm injection of single oocyte in natural cycle. J Assist Reprod Genetics 2002; 19: 127–31.
Vlaisavljević V, Reljič M, Gavrić-Lovrec V, Kovačič B. Comparable effectiveness using flexible single-dose antagonist (cetrorelix) and single dose long GnRH agonist (goserelin) protocol for in-vitro fertilisation cycles – a prospective randomised study. RBM Online 2003; 7: 301–8.
Vlaisavljević V, Kovačič B, Gavrić-Lovrec V, Reljič M, Petrovič V, Čižek Sajko M, Kovač V. Vpliv selekcije zarodkov na implantacijo zarodkov po prenosu v maternico. Zdrav Vestn 2002; 71: Suppl. I: 7–12.
Vlaisavljević V, Kovačič B, Reljič M, Gavrić-Lovrec V, Čižek-Sajko M. Is there any benefit from the culture of a single oocyte to a blastocyst-stage embryo in unstimulated cycles? Hum Reprod 2001; 16: 2379–83.
Vlaisavljević V, Borko E. Selective reduction after gamete intrafallopian transfer. Int J Obstet Gynecol 1991; 26: 59–61.
ASRM/SART. Assisted reproductive technology in the United States and Canada:1993 results generated from the American Society for Reproductive Medicine/Society for Assisted Reproductive Technology Registry. Fertil Steril 1995; 64: 13–21.
FIVNAT. Pregnancies and births resulting from in vitro fertilization: French national registry, analysis of data 1986 to 1990. Fertil Steril 1995; 64: 746–56.
Terlatzis B, Bili H. Survey on intracytoplasmic sperm injection: report from the ESHRE ICSI Task Force. Human Reprod 1998;13: Suppl 1: 165–77.
Vlaisavljević V, Gavrić-Lovrec V, Kovačič B, Reljič M, Kovač V, Petrovič V, Čižek-Sajko M. Uspješnost tehnika potpomognute oplodnje u žena starijih od 40 godina. Gynecol Perinatol 2002; 11: 15–8.
Reljič M, Vlaisavljević V, Gavrić V, Kovačič B. Number of oocytes retrieved and resulting pregnancy: risk factors for ovarian hyperstimulation syndrome. J Reprod Med 1999; 44: 713–8.
Kovačič B, Vlaisavljević V, Reljič M, Gavrić-Lovrec V. Clinical outcome of day 2 versus day 5 transfer in cycles with one or two developed embryos. Fertil Steril 2002; 77: 529–36.
Vlaisavljević V. Ishod trudnoća iz vantjelesne oplodnje. XLVII ginekološko akušerska nedelja SLD, Zbornik radova. Beograd: Srpsko lekarsko društvo, 2003: 1–8.
The Author transfers to the Publisher (Zdravniški vestnik/Slovenian Medical Journal) all economic copyrights following form Article 22 of the Slovene Copyright and Related Rights Act (ZASP), including the right of reproduction, the right of distribution, the rental right, the right of public performance, the right of public transmission, the right of public communication by means of phonograms and videograms, the right of public presentation, the right of broadcasting, the right of rebroadcasting, the right of secondary broadcasting, the right of communication to the public, the right of transformation, the right of audiovisual adaptation and all other rights of the author according to ZASP.
The aforementioned rights are transferred non-exclusively, for an unlimited number of editions, for the term of the statutory
The Author can make use of his work himself or transfer subjective rights to others only after 3 months from date of first publishing in the journal Zdravniški vestnik/Slovenian Medical Journal.
The Publisher (Zdravniški vestnik/Slovenian Medical Journal) has the right to transfer the rights, acquired parties without explicit consent of the Author.
The Author consents that the Article be published under the Creative Commons BY-NC 4.0 (attribution-non-commercial) or comparable licence.
