TREATMENT OF ENDOGENOUS FUNGAL ENDOPHTHALMITIS

  • Xhevat Lumi Očesna klinika Klinični center Zaloška 29/A 1525 Ljubljana
  • Mojca Globočnik Petrovič Očesna klinika Klinični center Zaloška 29/A 1525 Ljubljana
Keywords: endogenous fungal endophthalmitis, vitrectomy, amphothericin B, flukonazole, intravenous drug abusers

Abstract

Background. To report clinical findings and treatment possibilities of patients with endogenous fungal endophthalmitis.

Methods. Records of patients with endogenous fungal endophthalmitis treated at Eye Clinic from January 2000 to July 2003 were retrospectively reviewed. Information obtained from the medical record include the patient age, sex, causative organism, ocular treatment, systemic antifungal treatment, complications, length of follow-up and final visual outcome.

Results. 12 patients (13 eyes)were enrolled (9 males, 3 females, age 18 to 35). Clinical signs of infection cleared and visual acuity improved in all 13 eyes.

Conclusions. Pars plana vitrectomy in combination with intravitreal injection of amphotericin B and oral fluconazole is an effective alternative in managament of endogenous fungal endophthalmitis in selected cases.

Downloads

Download data is not yet available.

References

Brod RD, Flynn HW Jr, Miller DA. Endogenous fungal endophthalmitis. In: Tasman W, Jaeger E, eds. Duane’s clinical ophthalmology. Philadelphia: Lippincott, 1994; 6: 14–6.

Hamza HS, Loewenstein A, Haller JA. Fungal retinitis and endophthalmitis. Ophthal Clin North Am 1999; 12:

Aguilar GL, Blumenkranz MS, Egbert PR et al. Candida endophthalmitis after intravenous drug abuse. Arch Ophthalmol. 1979; 97: 96.

Essman TF, Flynn HW Jr, Smiddy WE, Brod RD, Murray TG, Davis JL, Rubsamen PE. Treatment outcomes in a 10-year study of endogenous fungal endophthalmitis. Ophthalmic Surg Lasers 1997; 28: 185–94.

Donahue SP, Greven CM, Zuravleff JJ et al. Intraocular candidiasis in patients with candidemia:clinical implications derived from a prospective multicenter study. Ophthalmology 1994; 101: 1302–9.

Christmas NJ, Smiddy WE. Vitrectomy and systemic fluconazole for treatment of endogenous fungal endophthalmitis. Ophthalmic Surg Lasers 1996; 27: 1012–8.

Brod RD, Flynn HW Jr, Clarkson JG et al. Endogenous Candida endophthalmitis: management without intravenous Amphotericin B. Ophthalmology 1990; 97: 666–74.

Schulman LA, Peyman GA. Intravitreal corticosteroids as an adjunct in the treatment of bacterial and fungal endophthalmitis. Retina 1992; 12: 336–40.

Brod RD, Flynn HW Jr. Advances in the diagnosis and treatment of infectious endophthalmitis. Curr Opin Ophthalmol 1991; 2: 306–14.

Luttrull JK, Wan WL, Kubak BM,Smith MD, Oster HA. Treatment of ocular fungal infections with oral fluconazole. Am J Ophthalmol 1995; 119: 477–81.

Coats ML, Peyman GA. Intravitreal corticosteroids in the treatment of exogenous fungal endophthalmitis. Retina 1992; 12: 46–51.

Laatiainen L, Tuominen M, Dickhoff K. Treatment of endogenous fungal endophthalmitis with systemic fluconazole with or without vitrectomy. Am J Ophthalmol 1992; 113: 205–7.

How to Cite
1.
Lumi X, Globočnik Petrovič M. TREATMENT OF ENDOGENOUS FUNGAL ENDOPHTHALMITIS. TEST ZdravVestn [Internet]. 1 [cited 5Aug.2024];73(5). Available from: http://vestnik-dev.szd.si/index.php/ZdravVest/article/view/2318
Section
Professional Article