BRONCHOSCOPY IN THE DIAGNOSIS AND THERAPY OF NOSOCOMIAL PNEUMONIA

  • Nikša Šegota Oddelek za bolezni srca, pljuč in ožilja, Splošna bolnišnica, Oblakova 5, 3000 Celje
  • Dragan Kovačič Oddelek za bolezni srca, pljuč in ožilja, Splošna bolnišnica, Oblakova 5, 3000 Celje
  • Vinko Božanič Laboratorij za medicinsko mikrobiologijo, Zavod za zdravstveno varstvo, Gregorčičeva 5, 3000 Celje
  • Rafael Skale Oddelek za intenzivno interno medicino, Splošna bolnišnica, Oblakova 5, 3000 Celje
  • Vesna Papuga Enota intenzivne medicine operativnih strok, Splošna bolnišnica, Oblakova 5, 3000 Celje
Keywords: bronchial aspirate, cultures, antibiotic resistance, nosocomial pneumony

Abstract

Background. The aim of our study was to evaluate the role of bronchoscopy in the diagnosis and treatment of hospital pneumonias by microbiological cultures obtained from bronchial aspirates.

Methods. We included all patients treated for hospital pneumonias during 1999 in General Hospital Celje (Division of cardiology and pulmonary medical care, internal and surgical intensive care unit) in whom bronchoscopy was performed. Only the patients with obtained microbiological cultures (isolation and bacterial sensitivity to antibiotics) were studied.

Results. We performed 112 bronchoscopies. Sixty-nine (62%) patients were males and 43 (38%) of female. Microbiological cultures were positive in 95 (85%) and negative in 17 (15%) specimens. Mortality rate was 32% and average length of stay was 14 days. The most frequently isolated bacteria was Pseudomonas aeruginosa (20 patients – 26%), followed by methicillin sensitive Staphylococcus aureus – MSSA in 14 patients. E. coli was present in 14 cultures and Streptococcus pneumoniae in 12 patients. Methicillin resistant Staphylococcus aureus – MRSA was found in 10 patients. Blood and central venous catheter clutures were positive in 10 patients. The same bacteria were also isolated in other specimens in 26 patients.

Conclusions. Bronchoscopy is an important aid in diagnosing hospital pneumonias. In high percentage it provides microbiological evaluation of bronchial aspirate, and has major impact in selection of an appropriate antibiotic treatment.

Downloads

Download data is not yet available.

References

Weber DJ, Rutala WA, Mayhall CG. Nosocomial respiratory tract infections and Gram-negative pneumonia. In: Fishman AP, Elias JA, Fishman JA et al. Fishman’s pulmonary diseases and disorders. 3rd ed. Vol. 2. New York: McGraw Hill, 1998: 2213–33.

Craven DE, Steger KA, Barber TW. Preventing nosocomial pneumonia: State of the art and perspectives for the 1990s. Am J Med 1991; 91 (3B): 44S–4S.

Scheld WM. Developments in the pathogenesis, diagnosis and treatment of nosocomial pneumonia. Surg Gynecol Obstet 1991; 172: Suppl: 42–2.

Centers for Disease Control and Prevention. Guideline for prevention of nosocomial pneumonia. Respir Care 1994; 39: 1191–1.

Fagon JY, Chastre J, Hance AJ et al. Nosocomial pneumonia in ventilated patients: a cohort study evaluating attributable mortality and hospital stay. Am J Med 1993; 94: 281–1.

Pingleton SK, Fagon JY, Leeper KV. Patient selection for clinical investigation of ventilator-associated pneumonia. Chest 1992; 102: Suppl: 553S–3S.

Craven DE, Stegar KA, Barat LM, Duncan RA. Nosocomial pneumonia: epidemiology and infection control. Intensive Care Med 1992: 18: S3–S9.

Rodrigues JL, Gibbons KJ, Bitzer LG, Dechert RE et al. Pneumonia: incidence, risk factors and outcome in injured patients. J Trauma 1991; 31: 904–14.

Craven DE, Kunches LM, Kilinsky V et al. Risk factors for pneumonia and fatality in patients receiving continuous mechanical ventilation. Am Rev Resp Dis 1986; 133: 792–2.

Craven DE, Steger KA. Epidemiology of nosocomial pneumonia. Chest 1995; 108: Suppl:1S–1S.

Garrouste-Oregeas M, Chevret S, Arlet G et al. Oropharyngeal or gastric colonisation and nosocomial pneumonia in adult intensive care patients. Am J Respir Crit Care Med 1997; 156: 1647–7.

Muzlovič I. Hospitalne pljučnice odraslih. In: Podiplomsko izobraževanje iz anesteziologije. Ljubljana: Slovensko zdravniško društvo, Slovensko združenje za anesteziologijo in intenzivno medicino, 1999: 65–77.

Timsit JF, Misset B, Azoulay E, Renaud B et al. Usefulness of airway visualisation in the diagnosis of nosocomial pneumonia in ventilated patients. Chest 1996; 110: 172–9.

Townsend GC, Scheld WM. Nosocomial pneumonia. Curr Opin Infect Dis 1995; 8: 98–104.

Bonten MJM, Bergmans DCJJ, Stobberingh EE, Van der Geest S et al. Implementation of bronchoscopic techniques in the diagnosis of ventilator-associated pneumonia to reduce antibiotic use. Am J Respir Crit Care Med 1997; 156: 1820–4.

Souweine B, Veber B, Bedos JP, Gachot B et al. Diagnostic accuracy of protected specimen brush and bronchoalveolar lavage in nosocomial pneumonia: impact of previous antimicrobial treatments. Crit Care Med 1998; 26: 236–44.

Levy H. Comparison of Ballard catheter bronchoalveolar lavage with bronchoscopic bronchoalveolar lavage. Chest 1994; 106: 1753–6.

Cook DJ, Brunbuisson C, Guyatt GH, Sibbald WJ. Evaluation of new diagnostic technologies – bronchoalveolar lavage and the diagnosis of ventilatorassociated pneumonia. Crit Care Med 1994; 22: 1314–22.

Kirtland HS, Corley DE, Winterbauer RH, Springmeyer SC et al. The diagnosis of ventilator-associated pneumonia. Chest 1997; 112: 445–57.

Albert S, Kirchner J, Thomas H, Behnes M et al. Role of quantitative cultures and microscopic examinations of endotracheal aspirates in the diagnosis of pulmonary infections in ventilated patients. J Hosp Inf 1997; 37: 25–37.

Niederman MS. An approach to empiric therapy of nosocomial pneumonia. Med Clin North Ann 1994; 78: 1123–41.

Muzlovič I. Zdravljenje bolnišnične pljučnice. Med Razgl 1995; 34: 521–8.

Mandell LA, Marrie TJ, Niederman MS. Initial antimicrobial of hospital acquired pneumonia in adults: a conference report. Can J Infect Dis 1993; 4: 317–21.

Hilf M, Yu VL, Sharp J et al. Antibiotic therapy for Pseudomonas aeruginosa bacteriemia: Outcome correlations in a prospective study of 200 patients. Am J Med 1989; 87: 540–0.

Chow JW, Fine MJ, Shlaes DM et al. Enterobacter bacteriemia: Clinical features and emergence of antibiotic resistance during therapy. Ann Intern Med 1991; 115: 585–5.

Celis R, Torres A, Gatell JM et al. Nosocomial pneumonia – a multivariate analysis of risk and prognosis. Chest 1988; 93: 318–8.

Chastre J, Trouillet JL, Vuagnat A, Joly-Guillou ML et al. Nosocomial pneumonia in patients with acute respiratory distress syndrome. Am J Respir Crit Care Med 1998; 157: 1165–72.

Baker AM, Meredith JW, Haponik EF. Pneumonia in intubated trauma patients. AMJ Respir Crit Care Med 1996; 153: 343–9.

Shigei J. Processing lower respiratory tract specimens. In: Isenberg HG ed. Essential procedures for clinical microbiology. Washington: ASM Press, 1998: 76–80.

National Committee for Clinical Laboratory Standards. Performance standards for antimicrobial disk susceptibility tests, 7th edition. Approved Standard M2-A7 and Supplement M100-S10. Wayne PA, NCCLS, 2000.

American Thoracic Society: Hospital-acquired pneumonia in adults: Diagnosis, assessment of severity, initial antimicrobial therapy, and preventive strategies. Am J Respir Crit Care Med 1996; 153: 1711–25.

Muzlovič I, Trampuž A. Hospital infection prevalence study in the intensive care units in Slovenia. In: Grosek Š, Dragaš AZ eds. Hospital hygiene and infection control in intensive care units. The IFIC workshop. Ljubljana: University medical centre, 1998: 100–4.

Bartlett JC, O‘Keefe P, Tally FP. Bacteriology of hospital-acquired pneumonia. Arch Intern Med 1991; 146: 868–71

How to Cite
1.
Šegota N, Kovačič D, Božanič V, Skale R, Papuga V. BRONCHOSCOPY IN THE DIAGNOSIS AND THERAPY OF NOSOCOMIAL PNEUMONIA. TEST ZdravVestn [Internet]. 1 [cited 5Aug.2024];70. Available from: http://vestnik-dev.szd.si/index.php/ZdravVest/article/view/2515
Section
Professional Article