LUNGS IN ANTIPHOSPHOLIPID SYNDROME – THREE CASE REPORTS
Abstract
Background. Three patients with antiphospholipid syndrome and lung involvement are presented. Except in one case, lung pathology was caused most probably by thrombotic and thrombembolic events in the lung circulation due to antiphospholipid syndrome. In one case however, equivalents of ARDS were observed with two differential diagnostic possibilities – catastrophic antiphospholipid syndrome and exacerbation of systemic vasculitis with secondary antiphospholipid activity.
Conclusions. We emphasize the possibility of lung involvement in antiphospholipid syndrome due to thrombotic and thrombembolic events in lung circulation.
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References
Kandiah DA, Sheng YH, Krilis SA. Beta 2-glycoprotein I: target antigen for autoantibodies in the antiphospholipid syndrome. Lupus 1996; 5: 381–5.
Shapiro SS. The lupus anticoagulant antiphospholipid syndrome. Ann Rev Med 1996; 47: 533–53.
Petri M. Pathogenesis and treatment of the antiphospholipid syndrome. Med Clin N Am 1997; 81: 151–77.
Lie JT. Vasculopathy of the antiphospholipid syndromes revisited: thrombosis is the culprit and vasculitis the consort. Lupus 1996; 5: 368–71.
Triplett DA. Protein clinical presentation of antiphospholipid – protein antibodies (APA). Thromb Haemost 1995; 74: 329–37.
Levy RA. Clinical manifestation of the aPL syndrome. Lupus 1996; 5: 393–7.
Hillerdal G. The lung physician and antiphospholipid syndrome. Eur Respir J 1997; 10: 511–2.
Remškar Z, Fras Z. Antifosfolipidni sindrom. Zdrav Vestn 1998; 67: 411–4.
Alarcon-Segovia D, Sanchez-Guerreo J. Primary antiphospholipid syndrome. J Rheumatol 1989; 16: 482–8.
Bowie EJW, Thomson JH, Pascuzzi CA, Owen CA. Thrombosis in systemic lupus erythematosus despite circulating anticoagulants. J Lab Clin Med 1963; 62: 416–30.
Cervera R, Asherson RA, Lie JT. Clinicopathologic correlation of the antiphospholipid syndrome. Semin Arthritis Rheum 1995; 24: 262–72.
Triplett DA, Asherson RA. Pathophysiology of the catastrophic antiphospholipid syndrome. Am J Haematol 2000; 65: 154–9.
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