The value of ultrasound in the diagnosis of brain damage in preterm infants
Abstract
Cranial ultrasonography (US) is a reliable tool to detect the most frequently occurring congenital and acquired brain abnormalities in preterm neonates. Appropriate equipment, including a dedicated ultrasound machine and appropriately sized transducers with special settings for cranial US of the newborn brain, and ample experience of the ultrasonographist are required to obtain optimal image quality. When, in addition, supplemental acoustic windows are used whenever indicated, and cranial US imaging is performed from admission throughout the neonatal period, the majority of the lesions will be diagnosed, and information on timing and evolution of brain injury as well as on ongoing brain maturation will be obtained. For exact determination of site and extent of lesions, for detection of lesions that (largely or partially) remain beyond the scope of cranial US and for depiction of myelination, a single, well-timed MRI examination is invaluable in many high-risk neonates. However, as cranial US allows serial bedside imaging it should be used as the primary brain imaging modality in high-risk neonates.
Downloads
References
de Vries LS, Benders MJ, Groenendaal F. Imaging the premature brain: ultrasound or MRI? Neuroradiology. 2013 Sep;55(S2 Suppl 2):13–22. https://doi.org/10.1007/s00234-013-1233-y PMID:23839652
van Wezel-Meijler G, Steggerda SJ, Leijser LM. Cranial ultrasonography in neonates: role and limitations. Semin Perinatol. 2010 Feb;34(1):28–38. https://doi.org/10.1053/j.semperi.2009.10.002 PMID:20109970
Steggerda SJ, Leijser LM, Walther FJ, van Wezel-Meijler G. Neonatal cranial ultrasonography: how to optimize its performance. Early Hum Dev. 2009 Feb;85(2):93–9. https://doi.org/10.1016/j.earlhumdev.2008.11.008 PMID:19144475
Steggerda SJ, De Bruïne FT, van den Berg-Huysmans AA, Rijken M, Leijser LM, Walther FJ, et al. Small cerebellar hemorrhage in preterm infants: perinatal and postnatal factors and outcome. Cerebellum. 2013 Dec;12(6):794–801. https://doi.org/10.1007/s12311-013-0487-6 PMID:23653170
Burja S, Japelj I, Tekavc-Golob A, Treiber M. Ultrazvok v diagnostiki zgodnje možganske oškodovanosti. In: Burja S, ur. Možgani, ranjeni v zgodnjem razvoju otroka: mednarodna znanstvena konferenca, učna delavnica s področja slikovne diagnostike z ultrazvokom: zbornik predavanj, Medicinska fakulteta Univerze v Mariboru; 2005. p.82–98.
Govaevrt P, de Vries LS. An Atlas of Neonatal Brain Sonography. 2nd ed. Mac Keith Press; 2010.
Meijler G. Neonatal Cranial Ultrasonography. 2nd ed. Springer; 2012. https://doi.org/10.1007/978-3-642-21320-5.
Raets MM, Sol JJ, Govaert P, Lequin MH, Reiss IK, Kroon AA, et al. Serial cranial US for detection of cerebral sinovenous thrombosis in preterm infants. Radiology. 2013 Dec;269(3):879–86. https://doi.org/10.1148/radiol.13130401 PMID:23985276
Leijser LM, Srinivasan L, Rutherford MA, van Wezel-Meijler G, Counsell SJ, Allsop JM, et al. Frequently encountered cranial ultrasound features in the white matter of preterm infants: correlation with MRI. Eur J Paediatr Neurol. 2009 Jul;13(4):317–26. https://doi.org/10.1016/j.ejpn.2008.06.005 PMID:18674940
Leijser LM, de Bruïne FT, Steggerda SJ, van der Grond J, Walther FJ, van Wezel-Meijler G. Brain imaging findings in very preterm infants throughout the neonatal period: part I. Incidences and evolution of lesions, comparison between ultrasound and MRI. Early Hum Dev. 2009 Feb;85(2):101–9. https://doi.org/10.1016/j.earlhumdev.2008.11.010 PMID:19144474
Fowlkes JB; Bioeffects Committee of the American Institute of Ultrasound in Medicine. American Institute of Ultrasound in Medicine consensus report on potential bioeffects of diagnostic ultrasound: executive summary. J Ultrasound Med. 2008 Apr;27(4):503–15. https://doi.org/10.7863/jum.2008.27.4.503 PMID:18359906
Papile LA, Burstein J, Burstein R, Koffler H. Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm. J Pediatr. 1978 Apr;92(4):529–34. https://doi.org/10.1016/S0022-3476(78)80282-0 PMID:305471
Babnik J. Možganska krvavitev nedonošenčka. In: Paro Panjan D, ur. Neonatalna Nevrologija: znanstvena monografija, Klinični oddelek za neonatologijo, Pediatrična klinika, UKC; 2014. p. 21–43. Babnik J, Stucin-Gantar I, Kornhauser-Cerar L, Sinkovec J, Wraber B, Derganc M. Intrauterine inflammation and the onset of peri-intraventricular hemorrhage in premature infants. Biol Neonate. 2006;90(2):113–21. https://doi.org/10.1159/000092070 PMID:16549908
Harteman JC, Groenendaal F, van Haastert IC, Liem KD, Stroink H, Bierings MB, et al. Atypical timing and presentation of periventricular haemorrhagic infarction in preterm infants: the role of thrombophilia. Dev Med Child Neurol. 2012 Feb;54(2):140–7. https://doi.org/10.1111/j.1469-8749.2011.04135.x PMID:22098125
Roberts D, Dalziel S. Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth. Cochrane Database Syst Rev. 2006 Jul;19(3):CD004454. PMID:16856047
Maller VV, Cohen HL. Neurosonography: Assessing the Premature Infant. Pediatr Radiol. 2017 Aug;47(9):1031–45. https://doi.org/10.1007/s00247-017-3884-z PMID:28779189
Levene MI. Measurement of the growth of the lateral ventricles in preterm infants with real-time ultrasound. Arch Dis Child. 1981 Dec;56(12):900–4. https://doi.org/10.1136/adc.56.12.900 PMID:7332336
Brouwer MJ, de Vries LS, Groenendaal F, Koopman C, Pistorius LR, Mulder EJ, et al. New reference values for the neonatal cerebral ventricles. Radiology. 2012 Jan;262(1):224–33. https://doi.org/10.1148/radiol.11110334 PMID:22084208
Nishimaki S, Iwasaki Y, Akamatsu H. Cerebral blood flow velocity before and after cerebrospinal fluid drainage in infants with posthemorrhagic hydrocephalus. J Ultrasound Med. 2004 Oct;23(10):1315–9. https://doi.org/10.7863/jum.2004.23.10.1315 PMID:15448321
Brouwer A, Groenendaal F, van Haastert IL, Rademaker K, Hanlo P, de Vries L. Neurodevelopmental outcome of preterm infants with severe intraventricular hemorrhage and therapy for post-hemorrhagic ventricular dilatation. J Pediatr. 2008 May;152(5):648–54. https://doi.org/10.1016/j.jpeds.2007.10.005 PMID:18410767
Tam EW, Miller SP, Studholme C, Chau V, Glidden D, Poskitt KJ, et al. Differential effects of intraventricular hemorrhage and white matter injury on preterm cerebellar growth. J Pediatr. 2011 Mar;158(3):366–71. https://doi.org/10.1016/j.jpeds.2010.09.005 PMID:20961562
Soltirovska Salamon A, Groenendaal F, van Haastert IC, Rademaker KJ, Benders MJ, Koopman C, et al. Neuro-imaging and neurodevelopmental outcome of preterm infants with a periventricular haemorrhagic infarction located in the temporal or frontal lobe. Dev Med Child Neurol. 2013.
Volpe JJ. Confusions in Nomenclature: “Periventricular Leukomalacia” and “White Matter Injury”-Identical, Distinct, or Overlapping? Pediatr Neurol. 2017 Aug;73:3–6. https://doi.org/10.1016/j.pediatrneurol.2017.05.013 PMID:28648484
Kinney HC, Haynes RL, Xu G, Andiman SE, Folkerth RD, Sleeper LA, et al. Neuron deficit in the white matter and subplate in periventricular leukomalacia. Ann Neurol. 2012 Mar;71(3):397–406. https://doi.org/10.1002/ana.22612 PMID:22451205
Volpe JJ. Systemic inflammation, oligodendroglial maturation, and the encephalopathy of prematurity. Ann Neurol. 2011 Oct;70(4):525–9. https://doi.org/10.1002/ana.22533 PMID:22028217
Counsell SJ, Allsop JM, Harrison MC, Larkman DJ, Kennea NL, Kapellou O, et al. Diffusion-weighted imaging of the brain in preterm infants with focal and diffuse white matter abnormality. Pediatrics. 2003 Jul;112(1 Pt 1):1–7. https://doi.org/10.1542/peds.112.1.1 PMID:12837859
Boardman JP, Craven C, Valappil S, Counsell SJ, Dyet LE, Rueckert D, et al. A common neonatal image phenotype predicts adverse neurodevelopmental outcome in children born preterm. Neuroimage. 2010 Aug;52(2):409–14. https://doi.org/10.1016/j.neuroimage.2010.04.261 PMID:20451627
Setänen S, Haataja L, Parkkola R, Lind A, Lehtonen L. Predictive value of neonatal brain MRI on the neurodevelopmental outcome of preterm infants by 5 years of age. Acta Paediatr. 2013 May;102(5):492–7. https://doi.org/10.1111/apa.12191 PMID:23398524
Limperopoulos C, Benson CB, Bassan H, Disalvo DN, Kinnamon DD, Moore M, et al. Cerebellar hemorrhage in the preterm infant: ultrasonographic findings and risk factors. Pediatrics. 2005 Sep;116(3):717–24. https://doi.org/10.1542/peds.2005-0556 PMID:16140713
Volpe JJ. Cerebellum of the premature infant: rapidly developing, vulnerable, clinically important. J Child Neurol. 2009 Sep;24(9):1085–104. https://doi.org/10.1177/0883073809338067 PMID:19745085
Steggerda SJ, Leijser LM, Wiggers-de Bruïne FT, van der Grond J, Walther FJ, van Wezel-Meijler G. Cerebellar injury in preterm infants: incidence and findings on US and MR images. Radiology. 2009 Jul;252(1):190–9. https://doi.org/10.1148/radiol.2521081525 PMID:19420320
Steggerda SJ, De Bruïne FT, van den Berg-Huysmans AA, Rijken M, Leijser LM, Walther FJ, et al. Small cerebellar hemorrhage in preterm infants: perinatal and postnatal factors and outcome. Cerebellum. 2013 Dec;12(6):794–801. https://doi.org/10.1007/s12311-013-0487-6 PMID:23653170
de Vries LS, Benders MJ, Groenendaal F. Imaging the premature brain: ultrasound or MRI? Neuroradiology. 2013 Sep;55(S2 Suppl 2):13–22. https://doi.org/10.1007/s00234-013-1233-y PMID:23839652
Niwa T, de Vries LS, Benders MJ, Takahara T, Nikkels PG, Groenendaal F. Punctate white matter lesions in infants: new insights using susceptibility-weighted imaging. Neuroradiology. 2011 Sep;53(9):669–79. https://doi.org/10.1007/s00234-011-0872-0 PMID:21553013
Iwata S, Nakamura T, Hizume E, Kihara H, Takashima S, Matsuishi T, et al. Qualitative brain MRI at term and cognitive outcomes at 9 years after very preterm birth. Pediatrics. 2012 May;129(5):e1138–47. https://doi.org/10.1542/peds.2011-1735 PMID:22529280
The Author transfers to the Publisher (Zdravniški vestnik/Slovenian Medical Journal) all economic copyrights following form Article 22 of the Slovene Copyright and Related Rights Act (ZASP), including the right of reproduction, the right of distribution, the rental right, the right of public performance, the right of public transmission, the right of public communication by means of phonograms and videograms, the right of public presentation, the right of broadcasting, the right of rebroadcasting, the right of secondary broadcasting, the right of communication to the public, the right of transformation, the right of audiovisual adaptation and all other rights of the author according to ZASP.
The aforementioned rights are transferred non-exclusively, for an unlimited number of editions, for the term of the statutory
The Author can make use of his work himself or transfer subjective rights to others only after 3 months from date of first publishing in the journal Zdravniški vestnik/Slovenian Medical Journal.
The Publisher (Zdravniški vestnik/Slovenian Medical Journal) has the right to transfer the rights, acquired parties without explicit consent of the Author.
The Author consents that the Article be published under the Creative Commons BY-NC 4.0 (attribution-non-commercial) or comparable licence.