THE EFFECT OF EARLY CERVICAL CANCER DIAGNOSIS

  • Herman Haller Department of Obstetrics and Gynecology, Clinical Hospital Centre of Rijeka, University of Rijeka, Cambierieva 17/5, 51000 Rijeka
  • Maja Krašević Department of Pathology, School of Medicine Rijeka, University of Rijeka, Cambierieva 13, 51000 Rijeka
  • Ozren Mamula Department of Obstetrics and Gynecology, Clinical Hospital Centre of Rijeka, University of Rijeka, Cambierieva 17/5, 51000 Rijeka
  • Danko Perović Department of Obstetrics and Gynecology, Clinical Hospital Centre of Rijeka, University of Rijeka, Cambierieva 17/5, 51000 Rijeka
  • Alenka Brnčić-Fischer Department of Obstetrics and Gynecology, Clinical Hospital Centre of Rijeka, University of Rijeka, Cambierieva 17/5, 51000 Rijeka
  • Senija Eminović Department of Pathology, School of Medicine Rijeka, University of Rijeka, Cambierieva 13, 51000 Rijeka
  • Danijela Vrdoljak-Mozetič Division of gynecologic cytology, Department of Obstetrics and Gynecology, Clinical Hospital centre of Rijeka, University of Rijeka, Cambierieva 17/5, 51000 Rijeka
  • Miroslav Stamatović Department of Obstetrics and Gynecology, Clinical Hospital Centre of Rijeka, University of Rijeka, Cambierieva 17/5, 51000 Rijeka
  • Miljenko Manestar Department of Obstetrics and Gynecology, Clinical Hospital Centre of Rijeka, University of Rijeka, Cambierieva 17/5, 51000 Rijeka
Keywords: cervical cancer, conization, hysterectomy, FIGO, radical hysterectomy

Abstract

Background: Treatment effectiveness and clinical outcome of patients with cervical carcinoma FIGO stage IA1 and IA2 are analyzed in three different time period at the Department of Obstetrics and Gynecology Rijeka, Croatia.

Method: Retrospective analysis of the hospital chart of all cervical cancer patients between 1991 and 2005 was conducted with five-year follow up.

Results: Data on cervical cancer distribution by stage and five-year survival are presented. Separately analyzed age, histology type and treatment modalities in stage FIGO IA1 and IA2 during three consecutive five-year periods are presented.

Conclusions: Conservative surgical approach – conization alone in stage IA1 of the squamous cell car- cinoma is reasonable and safe treatment option for reproductive active women. During observed periods conization became the most used surgical technique applied in almost two third of FIGO IA1 cervical cancer patients. Lymph vascular space invasion in stage IA1 lead to adjunct pelvic lymphadenectomy with unclear clinical benefit. In cervical cancer patients stage IA2 simple hysterectomy and pelvic lymphadenectomy could be accepted as a standard treatment. In these patients further studies are recommended to evaluate other less radical surgical techniques – simple and radical trachelectomy with or without pelvic lymphadenectomy. Radical hysterectomy in both stages IA1 and IA2, based on personal experience and literature data represents a surgical overtreatment and should be abandoned.

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References

Creasman WT. New gynecologic cancer staging. Gynecol Oncol 1995; 58: 157–8.

KolstadP.Follow-upstudyof232patientswithstageIa1and411 patients with stage Ia2 squamous cell carcinoma of the cervix (microinvasive carcinoma). Gynecol Oncol 1989; 33:265–72.

Burghardt E, Girardi F, Lahousen M, Pickel H, Tamussion K. Microinvasive carcinoma of the uterine cervix. (International Federation of Gynecology and Obstetrics Stage IA). Cancer 1991; 67: 1037–45.

Benedet JL, Anderson GH. Stage IA carcinoma of the cervix revisited. Obstet Gynecol 1996; 87: 1052–9.

Creasman WT, Zaino RJ, Major FJ, DiSaia PJ, Hatch KD, Homesley HD. Early invasive carcinoma of the cervix (3 to 5 mm invasion): risk factors and prognosis. A Gynecologic Oncology Group study. Am J Obstet Gynecl 1998; 178: 62–65.

Dargent D, Martin X, Sacchetoni A, Mathevet P. Laparoscopic vaginal radical trachelectomy: A treatment to preserve the fertility of cervical carcinoma patients. Cancer 2000; 88: 1877–82.

Quinn MA, Benedet JL, Odicino F, Maisonneuve P, Beller U, Creasman WT. Carcinoma of the cervix uteri. FIGO Annual Report on the Results of Treatment in Gynecological Cancer. Int J Gynecol Obstet 2006; 95 Suppl 1: S43–103.

Jones WB, Mercer GO, Lewis JL Jr, Rubin SC, Hoskins WJ. Early invasive carcinoma of the cervix. Gynecol Oncol 1993; 51: 26–32.

HallerH,RupčićS,KraševićM,BegonjaR,StamatovićM,Mamula O. Treatment of invasive cervical cancer: Rijeka Experience. Coll Antropol 2007; 31: 139–46.

MottaF.Microinvasivesquamouscarcinomaofthecervix:treat- ment modalities. Acta Obstet Gynecol Scand 2003; 82: 505–9.

Van Nagell J, Greenwell N, Powell D, Donaldson ES, Hanson MB, Gay EC. Microinvasive carcinoma of the cervix. Am J Obstet Gynecol 1983; 145: 981–91.

RaspagliesiF,DitoA,QuattroneP,SolimaE,FontanelliR,Dousias V, et al. Prognostic factors in microinvasive cervical squamous cell cancer: long term results. Int J Gynecol Cancer 2005; 15: 88–93.

OstorAG.Studieson200casesofearlysquamouscellcarcinoma of the cervix. Int J Gynecol Pathol 1993; 12: 193–207.

Lin H, Chang Y, Huang CC, Changchien CC. Prediction of disease persistence after conization for microinvasive cervical carcinoma and cervical intraepithelial neoplasia grade 3. Int J Gynecol Cancer 2004; 14: 311–6.

Gadducci A, Sartori E, Maggino T, Landoni F, Zola P, Cosio S, et al. The clinical outcome of patients with Stage Ia1 and Ia2 squamous cell carcinoma of the uterine cervix. A Cooperation Task Force (CTF) study. Eur J Gynaecol Oncol 2003; 24: 513–6.

Phongnarisorn C, Srisomboon J, Khunamornpon S, Siriaung- kul S, Suprasert P, Charoenkwan K, et al. The risk of residual neoplasia in women with microinvasive squamous cervical carcinoma and positive cone margins. Int J Gynecol Cancer 2006; 16: 655–9.

Park JY, Lee SM, Yoo CW, Kang S, Park SY, Seo SS. Risk factors predicting residual disease in subsequrnt hysterectomy follow- ing conization for cervical intraepithelial neoplasia (CIN) III and microinvasive cervical cancer. Gynecol Oncol 2007; 107: 39–44.

MorrisM,MitchellM,SilvaE,CoppelandL,GershensonD.Cervi- cal conization as a definitive therapy for early invasive squamous carcinoma of the cervix. Gynecol Oncol 1993; 51:193–6.

Monk A, Pushkin S, Nelson A, Gunning J. Conservative manage- ment of options for patients with dysplasia involving cervical margins of cervical cone biopsy specimen. Am J Obstet Gynecol 1996; 174: 1695–700.

Greer BE, Figge DC, Tamimi HK, Cain JM, Lee RB. Stage IA2 squamous carcinoma of the cervix: difficult diagnosis and therapeutic dilemma. Am J Obstet Gynecol 1990; 162: 1406–9.

Prato B, Ghelardi A, Gadducci A, Marchetti I, Di Cristofano C, Di Coscio G, et al. Correlation of recurrence rates and times with posttreatment human papillomavirus status in patients treated with loop electrosurgical excision procedure conization for cervical squamous intraepithelial lesions. Int J Gynecol Cancer. 2008; 18: 90–4.

Takeshima N, Yanoh K, Tabata T, Nagai K, Hirai Y, Hasumi K. Assessment of the revised International Federation of Gynecol- ogy and Obstetrics staging for early invasive squamous cervical cancer. Gynecol Oncol 1999; 74: 165–9.

Sedlis A, Sall S, Tsukada Y, Park R, Mangan C, Shingleton H, et al. Microinvasive carcinoma of the uterine cervix: a clinical- pathologic study. Am J Obstet Gynecol 1979; 133: 64–74.

Maiman MA, Fruchter RC, DiMaio TM, Boyce JC. Superficially invasive squamous cell carcinoma of the cervix. Obstet Gynecol 1988,72: 399–403.

Copeland LJ, Silva EG, Gershenson DM, Morris M, Young DC, Wharton JT. Superficially invasive squamous cell carcinoma of the cervix. Gynecol Oncol 1992; 45: 307–12.

Lee KB, Lee JM, Park CY, Lee KB, Cho HY, Ha SY. Lymph node metastasis and lymph vascular space invasion in microinvasive squamous cell carcinoma of the uterine cervix. Int J Gynecol Cancer 2006; 16:1184–7.

Rob L, Charvat M, Robova H, Pluta M, Strnad P, Hrehorcak M, et al. Less radical fertility-sparing surgery than radical trachelectomy in early cervical cancer. Int J Gynecol Cancer 2007; 17:304–10.

Landoni F, Parma G, Peiretti M, Zanagnolo V, Sideri M, Colombo N, et al. Chemo-conization in early cervical cancer. Gynecol Oncol 2007; 107 Suppl 1: S125–6.

Bisseling KC, Bekkers RL, Rome RM, Quin MA. Treatment of micro-invasive adenocarcinoma of the uterine cervix: a retro- spective study and review of the literature. Gynecol Oncol 2007; 107: 424–30.

Published
2018-02-14
How to Cite
1.
Haller H, KraševićM, Mamula O, PerovićD, Brnčić-FischerA, EminovićS, Vrdoljak-MozetičD, StamatovićM, Manestar M. THE EFFECT OF EARLY CERVICAL CANCER DIAGNOSIS. TEST ZdravVestn [Internet]. 14Feb.2018 [cited 5Aug.2024];78. Available from: http://vestnik-dev.szd.si/index.php/ZdravVest/article/view/2731
Issue
Vol 78 (2009): Supplement I
Section
Review


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