Acute traumatic spinal cord injury
Pathophysiology and modern treatment concepts
Abstract
Traumatic spinal cord injury (tSCI) is a devastating event with huge impact on modern society. Despite recent advancements in different therapeutic strategies in preclinical models the transition of these approaches into the clinical setting remains elusive. However, recent studies showed that urgent spinal cord decompression and adequate spinal cord perfusion have a positive effect on neurologic recovery. Additional treatment strategies that try to address the complexity of tSCI are under clinical investigation and follow a superior understanding of pathophysiologic processes involved in tSCI. Therefore, in this review we present a comprehensive understanding of pathophysiologic processes involved in tSCI with emerging and evolving concepts of modern treatment.
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