Frequency and coexistence of recurrent chromosomal aberrations in multiple myeloma patients
Abstract
Background: The genome of myeloma plasma cells is characterized by marked instability comprising both complex numeric and structural abnormalities. Recent data in the literature suggest that multiple myeloma (MM) is also associated with deletion of 1p, amplification of 1q, deletion of 6q and amplification of 15q. These chromosomal aberrations have an impact on MM prognosis. We have looked for above mentioned chromosomal abnormalities in 68 newly diagnosed MM patients. Furthermore, our aim was to establish whether certain chromosomal abnormalities occur together with the others or exclusively autonomously. Methods: Chromosomal aberrations were detected using commercially available FISH DNA probes. Results: Deletion of 1p, amplification of 1q, deletion of 6q and amplification of 15q were present in 10 %, 40 %, 10 % and 47 % of patients, respectively. Our results confirm that amplification of 1q and del(13)(q14.3) are highly associated. We also detected an association between amplification of 1q and t(4;14)(p16.3;q32), and del(17)(p13.1). Additionally, the association between amplification of 15q and del(17)(p13.1), and del(6q) was statistically confirmed. Conclusions: Literature data confirm the prognostic significance of newly tested chromosomal abnormalities in MM patients. Since they are frequent in our group of MM patients, the addition of DNA-probes into MM FISH probe panel has a substantial meaning for their detection .Downloads
The Author transfers to the Publisher (Zdravniški vestnik/Slovenian Medical Journal) all economic copyrights following form Article 22 of the Slovene Copyright and Related Rights Act (ZASP), including the right of reproduction, the right of distribution, the rental right, the right of public performance, the right of public transmission, the right of public communication by means of phonograms and videograms, the right of public presentation, the right of broadcasting, the right of rebroadcasting, the right of secondary broadcasting, the right of communication to the public, the right of transformation, the right of audiovisual adaptation and all other rights of the author according to ZASP.
The aforementioned rights are transferred non-exclusively, for an unlimited number of editions, for the term of the statutory
The Author can make use of his work himself or transfer subjective rights to others only after 3 months from date of first publishing in the journal Zdravniški vestnik/Slovenian Medical Journal.
The Publisher (Zdravniški vestnik/Slovenian Medical Journal) has the right to transfer the rights, acquired parties without explicit consent of the Author.
The Author consents that the Article be published under the Creative Commons BY-NC 4.0 (attribution-non-commercial) or comparable licence.
