INFLUENCE OF ETHANOL AND ITS FIRST METHABOLITE ACETALDEHYDE ON THE CENTRAL NERVOUS SYSTEM
Abstract
Background Ethanol, a legal drug, is a big social problem in our country. First of all because of addiction development and also due to consequences of the chronic alcoholism. Ethanol effects to almost all organ systems. Consequences of its both, acute and chronic effects, are visible especially in the central nervous system (CNS). Mechanisms of ethanol toxic effects have been already well researched. Lately, many studies attributed at least a part of ethanol effects to its first metabolite acetaldehyde which is produced, mainly with catalase, in the CNS. Acetaldehyde should have key role in the chronic ethilism development. Conclusions Effects of ethanol on the CNS are well known, and its main toxic mechanisms on the CNS have been getting more and more known/researched. Last studies showed that acetaldehyde alone shows effects similar to ethanol. Similar are also some known mechanism of acetaldehyde action. “The most ethanol effects are consequence of its first metabolite action” is still speculative statement, until it will be confirmed that such acetaldehyde effects could be developed by acetaldehyde concentrations accessible in the brain after individual drinking of ethanol.Downloads
The Author transfers to the Publisher (Zdravniški vestnik/Slovenian Medical Journal) all economic copyrights following form Article 22 of the Slovene Copyright and Related Rights Act (ZASP), including the right of reproduction, the right of distribution, the rental right, the right of public performance, the right of public transmission, the right of public communication by means of phonograms and videograms, the right of public presentation, the right of broadcasting, the right of rebroadcasting, the right of secondary broadcasting, the right of communication to the public, the right of transformation, the right of audiovisual adaptation and all other rights of the author according to ZASP.
The aforementioned rights are transferred non-exclusively, for an unlimited number of editions, for the term of the statutory
The Author can make use of his work himself or transfer subjective rights to others only after 3 months from date of first publishing in the journal Zdravniški vestnik/Slovenian Medical Journal.
The Publisher (Zdravniški vestnik/Slovenian Medical Journal) has the right to transfer the rights, acquired parties without explicit consent of the Author.
The Author consents that the Article be published under the Creative Commons BY-NC 4.0 (attribution-non-commercial) or comparable licence.