DNA PLOIDY AND NUCLEAR TEXTURE FEATURES OF THERETICULAR FORM OF ORAL LICHEN PLANUS
Abstract
BACKGROUND Oral lichen planus (OLP) is a chronic inflammatory disease of the oral mucosa with lowrisk of malignant transformation. At present there are no reliable tools to predict whichOLP will progress to cancer. Abnormal DNA content has been reported to be a valuablediagnostic marker of potential malignant transformation of oral white patches.Aims To analyze image cytometric DNA ploidy of OLP and assess chromatin changes reflectedin nuclear features, when OLP is compared to normal buccal mucosa.Materials and Twenty-eight patients with reticular form of OLP and 50 healthy control subjects weremethods included in the study. No malignant transformation of OLP was observed during a followupperiod of 25 years. Scrapings of buccal mucosa were suspended in transport medium.Monolayer filter cell preparations were Feulgen-Thionin stained. Image cytometric analysiswas performed by Cyto-Savant system. RESULTS All OLP in our study were diploid. Statistically significant differences were found betweennormal buccal mucosa and OLP in several nuclear texture features. CONCLUSIONS Our results indicate that diploidy predominates in OLP, confirming its benign nature.Minor chromatin changes of OLP were detected by IC, probably of reactive typeDownloads
The Author transfers to the Publisher (Zdravniški vestnik/Slovenian Medical Journal) all economic copyrights following form Article 22 of the Slovene Copyright and Related Rights Act (ZASP), including the right of reproduction, the right of distribution, the rental right, the right of public performance, the right of public transmission, the right of public communication by means of phonograms and videograms, the right of public presentation, the right of broadcasting, the right of rebroadcasting, the right of secondary broadcasting, the right of communication to the public, the right of transformation, the right of audiovisual adaptation and all other rights of the author according to ZASP.
The aforementioned rights are transferred non-exclusively, for an unlimited number of editions, for the term of the statutory
The Author can make use of his work himself or transfer subjective rights to others only after 3 months from date of first publishing in the journal Zdravniški vestnik/Slovenian Medical Journal.
The Publisher (Zdravniški vestnik/Slovenian Medical Journal) has the right to transfer the rights, acquired parties without explicit consent of the Author.
The Author consents that the Article be published under the Creative Commons BY-NC 4.0 (attribution-non-commercial) or comparable licence.
