Modern biological treatments of depression
Abstract
The monoamine hypothesis of depression proposes the lowering of serotonin and noradrenaline concentrations in the brain as potential causes for development of depressive disorder. Recently, this hypothesis has been replaced by different kinds of other biochemical hypotheses about depression. Among them, neurotrophic hypothesis has the largest support of experimental evidence. Depression is perhaps not caused by purely biochemical mechanisms but is related to disturbances in information processing in specific, emotional networks of the brain. According to this view, antidepressants work because they alter conditions for activity-dependent changes in the plasticity of these networks. In the article we review the current evidence for possible biological hypotheses about depression and relate them to different kinds of modern biological therapies of depression.Downloads
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