Biliary atresia in Slovenia Congenital extrahepatic biliary atresia in children in Slovenia – epidemiological retrospective data
Abstract
Backg round: The objective of this study was to investigate the history, clinical, laboratory, imaging data and outcome of children with biliary atresia in Slovenia. Methods: In an epidemiological single-arm retrospective study health records of infants born in Slovenia between October 1996 and October 2011, who were diagnosed with biliary atresia at the University Children’s Hospital, University Medical Centre Ljubljana, were reviewed. Epi-demiological data and outcomes of patients with biliary atresia in Slovenia were studied. Results: In the 15-year period, 16 cases of biliary atresia were confirmed (1/20000 newborns). Two thirds of patients in our cohort were females. One child had associated laterality malformation. The majority of patients were born in autumn and winter months. The affected newborns were born mature with appropriate birth measures and healthy, but most of them became jaundiced in the first days of life. Primary surgery was done in 11 children at median age of 70 days. Of those children in whom the surgery was unsuccessful, 13 (81 %) underwent liver transplantation in foreign surgical centres. Median age at liver transplantation was 9 months, median time from Kasai operation to liver transplantation was 5 months. Median follow-up was 9.75 years (range 1.2–15.4). Conclusions: In Slovenia, the incidence of biliary atresia is low and biliary atresia splenic malformation very rare. The observed seasonal incidence might suggest the viral aetiology.Downloads
The Author transfers to the Publisher (Zdravniški vestnik/Slovenian Medical Journal) all economic copyrights following form Article 22 of the Slovene Copyright and Related Rights Act (ZASP), including the right of reproduction, the right of distribution, the rental right, the right of public performance, the right of public transmission, the right of public communication by means of phonograms and videograms, the right of public presentation, the right of broadcasting, the right of rebroadcasting, the right of secondary broadcasting, the right of communication to the public, the right of transformation, the right of audiovisual adaptation and all other rights of the author according to ZASP.
The aforementioned rights are transferred non-exclusively, for an unlimited number of editions, for the term of the statutory
The Author can make use of his work himself or transfer subjective rights to others only after 3 months from date of first publishing in the journal Zdravniški vestnik/Slovenian Medical Journal.
The Publisher (Zdravniški vestnik/Slovenian Medical Journal) has the right to transfer the rights, acquired parties without explicit consent of the Author.
The Author consents that the Article be published under the Creative Commons BY-NC 4.0 (attribution-non-commercial) or comparable licence.