Succesful use of theoretically calculated dosage of sugammadex for routine reversal of vecuronium-induced muscle relaxation
Abstract
Background: Sugamadex (Bridion) is a new drug that neutralizes neuromuscular block caused by amniosteroidal muscle relaxants. The data about exact dosage of sugamadex for routine neutralization of neuromuscular block caused by vecuronium is scarce as the number of trails regrading the use of sugamadex to neutralize neuromuscular block caused by vecuronium are very limited. Patients and methods: In this article we report two patients in whom muscular relaxation was induced by vecuronium for the purpose of general anesthesia for scheduled abdominal surgery. At the end of surgery muscle relaxation was neutralised with sugamadex with vecuronium dosege adjusted according to our theoretical calculations. In both cases we used sigificantly smaller dosages of sugmmadex than recommended by the manufacturer. We discuss why would these theoretically calculated dosages be sufficient for routine reversal of vecuroniuminduced muscle relaxation. Conclusion: In both cases we achieved complete reversal of vecuronium induced muscle relaxation with theoretically ajusted dosage of sugamadex.Downloads
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