Investigation of suspected TRALI cases in 2006–2011
Abstract
Introduction: Three decades ago, transfusionrelated acute lung injury (TRALI) became an independent clinical entity. In the following years it was recognized among the most common transfusion-related major morbidity and mortality causes. Consequently, preventive measures were introduced that reduced severe immune (antibody-mediated) TRALI cases. Since the first publications, immune (antibody-mediated) TRALI was associated with leukocyte antibodies of predominantly donor origin, which cause activation of recipient neutrophils in the lung and consequently an acute lung injury. In predisposed, severely ill patients soluble neutrophilpriming substances that accumulate in stored cellular blood components can trigger non-immune (antibody-independent) TRALI. Methods: In 2006–2011, eight suspected TRALI cases that met consensus clinical criteria and had chest radiograph were investigated in the Blood Transfusion Center of Slovenia. Patients and all donors of blood components transfused within 6 hours before the onset of acute respiratory distress were investigated for leukocyte antibodies against HLA class I and II antigens, and antibodies against neutrophil antigens HNA. All cases were investigated for patient, donor and blood component characteristics. In cooperation with clinicians, chest radiographs and alternative risk factors for acute lung injury (ALI) were evaluated.Downloads
The Author transfers to the Publisher (Zdravniški vestnik/Slovenian Medical Journal) all economic copyrights following form Article 22 of the Slovene Copyright and Related Rights Act (ZASP), including the right of reproduction, the right of distribution, the rental right, the right of public performance, the right of public transmission, the right of public communication by means of phonograms and videograms, the right of public presentation, the right of broadcasting, the right of rebroadcasting, the right of secondary broadcasting, the right of communication to the public, the right of transformation, the right of audiovisual adaptation and all other rights of the author according to ZASP.
The aforementioned rights are transferred non-exclusively, for an unlimited number of editions, for the term of the statutory
The Author can make use of his work himself or transfer subjective rights to others only after 3 months from date of first publishing in the journal Zdravniški vestnik/Slovenian Medical Journal.
The Publisher (Zdravniški vestnik/Slovenian Medical Journal) has the right to transfer the rights, acquired parties without explicit consent of the Author.
The Author consents that the Article be published under the Creative Commons BY-NC 4.0 (attribution-non-commercial) or comparable licence.