INFLUENCE OF LOCAL HORMONE REPLACEMENT THERAPY ON MICTURITIONDISORDERS IN POSTMENOPAUSE
Abstract
BACKGROUND Numerous epidemiologic studies have shown that over 50 % of postmenopausal womenexperience micturition disorders as part of urogenital syndrome. Due to hormone deficiency and biologic process of aging, the incidence of micturition disorders increases withincreasing age. Stress urinary incontinence and mixed urinary incontinence are morefrequent to the age of 65 years, and afterwards the incidence of urge urinary incontinenceincreases. METHODS In an observational study on Vagifem®, over 300 women with urogenital disorders fromthe entire county were included by the Slovenian gynecologists in the time period fromMay 2006 to July 2007. The aim of the study was to observe the effects of the treatment withlocal application of tablets 17 ß-estradiol (Vagifem®, Novo Nordisk A/S) after 3 and 6months of treatment. The analysis involved data on 282 women. The efficacy and safety oflocal hormonal treatment were evaluated on the basis of subjective parameters, providedby the women on admission and 3 and 6 months in the form of answers to a validatedquestionnaire. RESULTS Three-month local application of hormonal tablets statistically significantly decreased thepercentage of women complaining of constant feeling of needing to urge to void and painin the bladder area before treatment. The percentage of women complaining of stressand/or urge urinary incontinence before treatment also decreased, and so did thefrequency of miction and the percentage of women complaining of burning sensationwhen voiding. CONCLUSIONS In this study we provide evidence that vaginal application of small doses of estradiol (25micrograms of natural 17 ß-estradiol) substantially appease micturition disorders, consequences of urogenital atrophy, after a few months of treatment. As it has been found that10–25 % of postmenopausal women receiving systemic hormonal replacement therapystill experience problems due to urogenital atrophy, we may conclude that complementaryvaginal application of low dose estradiol is useful in eliminating micturition disorders thataccompany urogenital aging in postmenopauseDownloads
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