SPECT IMAGING OF DOPAMINE TRANSPORTER IN BRAIN DISORDERS
Abstract
BACKGROUND Diagnosis of parkinsonism is based on medical history and clinical examination. Whenthe signs of parkinsonism are obvious (tremor at rest, rigidity, bradykinesia), the diagnosisis relatively easy. However, problems appear when clinical signs are not typical or distinctenough for making the proper diagnosis. Dopamine transporter imaging with radioactivetracer 123I-Ioflupane (DAT-SPECT) enables a clear evaluation of nigrostriatal degeneration and helps a clinician to make a correct diagnosis. This article discusses the role andindications of DAT-SPECT imaging in patients with movement disorders and in patientswith dementia. CONCLUSIONS DAT-SPECT enables clear differentiation of degenerative parkinsonisms from parkinsonisms and non-parkinsonian tremors in which the nigrostriatal pathway remains intact.DAT-SPECT also differentiates dementia with Lewy bodies from Alzheimer’s diseaseDownloads
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