Determination of criteria for the assessment of embryo quality with good implantation predictability on a model of unstimulated in vitro fertilization cycles – Prediction of implantation in unstimulated cycles
Abstract
Background: In unstimulated in vitro fertilization cycles we analysed which criteria for the assessment of day-3-embryo quality were the most important predictive factors of successful implantation. Methods: A retrospective analysis of 115 unstimulated in vitro fertilization (IVF) cycles, terminated by embryo transfer (ET) on day 3 post follicular aspiration, was done. The embryos were evaluated according to three criteria: (i) blastomere fragmentation, (ii) blastomere number on the day of ET and (iii) blastomere cleavage dynamics. The impact of individual criteria, and of combinations of several criteria for embryo quality assessment, on implantation was established. Results: The impact of embryo quality on implantation could only be confirmed in the case when the embryo was evaluated on the basis of blastomere fragmentation and blastomere cleavage dynamics simultaneously (χ2 = 5.23; P< 0.05). In such cases the implantation rate amounted to 27.0 % (20/74) in good quality embryos and 9.8 % (4/41) in poor quality embryos. The predictive value of implantation for the so defined embryo quality was 3.43 (95 % CI = 1.08–10.84). Conclusion: Embryo quality, defined by blastomere fragmentation and blastomere cleavage dynamics simultaneously, proved to be a good predictive factor of implantation. In good quality embryos, the odds for implantation were 3.43 times higher than in embryos of poor quality.Downloads
The Author transfers to the Publisher (Zdravniški vestnik/Slovenian Medical Journal) all economic copyrights following form Article 22 of the Slovene Copyright and Related Rights Act (ZASP), including the right of reproduction, the right of distribution, the rental right, the right of public performance, the right of public transmission, the right of public communication by means of phonograms and videograms, the right of public presentation, the right of broadcasting, the right of rebroadcasting, the right of secondary broadcasting, the right of communication to the public, the right of transformation, the right of audiovisual adaptation and all other rights of the author according to ZASP.
The aforementioned rights are transferred non-exclusively, for an unlimited number of editions, for the term of the statutory
The Author can make use of his work himself or transfer subjective rights to others only after 3 months from date of first publishing in the journal Zdravniški vestnik/Slovenian Medical Journal.
The Publisher (Zdravniški vestnik/Slovenian Medical Journal) has the right to transfer the rights, acquired parties without explicit consent of the Author.
The Author consents that the Article be published under the Creative Commons BY-NC 4.0 (attribution-non-commercial) or comparable licence.