EPIDEMIOLOGICAL ASSESSMENT OF THE PREVALENCE OF GASTROESOPHAGEAL REFLUX DISEASE IN SLOVENIA

  • Gregor Pleterski Krka, d. d. Dunajska c. 65 1000 Ljubljana
  • Marijan Ivanuša Krka, d. d. Dunajska c. 65 1000 Ljubljana
  • Jože Drinovec Krka, d. d. Dunajska c. 65 1000 Ljubljana
  • Aleš Mrhar Fakulteta za farmacijo Aškerčeva 7 1000 Ljubljana
Keywords: gastroesophageal reflux disease (GERD), esophagitis, prevalence

Abstract

Background. No adequate epidemiological study of gastroesophageal reflux disease (GERD) has as yet been conducted in Slovenia. This epidemiological study provided data on the frequency of upper gastrointestinal tract endoscopies in a limited geographic region. The obtained data were used for a projection of the epidemiological situation of GERD in Slovenia. Over a period of 24 working days, the inhabitants of the Gorenjska region underwent 859 endoscopies (50.8% of the patients were males). Esophagitis was diagnosed in 167 patients (19.5% of the total number of the patients examined) of whom 102 were of male and 65 of female sex. The most frequently diagnosed condition was gastritis (139 patients). Other very frequently obtained findings included hiatal hernia, duodenitis and a normal finding. Our calculation revealed that approximately 9000 patients consulted a general practitioner due to GERD symptoms in the year 2000. Our calculations were made on the assumption that general practitioners refer 50% of the patients to a specialist and that esophagitis is endoscopically diagnosed in 40% of GERD patients.

Conclusions. Considering that, according to literature data, 25% of patients with dyspeptic symptoms visit a physician, the calculated prevalence of GERD among the population between 10 and 89 years comes to 20.5%. Projection of this figure to the entire Slovenia gives the number of people suffering from the reflux disease and which is over 363,000.

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References

Dent J. Gastro-oesophageal reflux disease. Digestion 1998; 59: 433–45.

Pernat C. Epidemiologija in simptomatika gastroezofagealne refluksne bolezni. In: Hojs R, Kranjc I. 10. srečanje internistov in zdravnikov splošne medicine: Iz prakse za prakso. Maribor: Splošna bolnišnica, 1999: 209–17.

Gottlieb S. Reflux increases risk of adenocarcinoma of esophagus. BMJ 1999; 318: 827–7.

Lagergren J, Bergstrom R, Lingren A, Nyren O. Symptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma. N Engl J Med 1999; 340: 825–31.

Cohen S, Parkman HP. Heartburn – a serious symptom. N Engl J Med 1999; 340: 878–9.

Kocijančič B, Ivanuša M. Gastroezofagealna refluksna bolezen pri odraslih. Zdrav Vestn 2000; 69: 531–6.

Locke GR III, Talley NJ, Fett SL, Zinsmeister AR, Melton LJ. Prevalence and clinical spectrum of gastroesophageal reflux: A population-based study in Olmsted country, Minnesota. Gastroenterol 1997; 112: 1448–56.

Heading RC. Prevalence of upper gastrointestinal symptoms in the general population: A systematic review. Scand J Gastroenterol 1999; 34: Suppl 231: 3–8.

Brady WM. Gastroesophageal reflux disease. Drugs of Today 1998; 34: 25–30.

Schindlbeck NE. Gastroesophageale Refluxkrankheit – Epidemiologie, Diagnostik und klinischer Verlauf. Int Welt Gastro 1995: 7–8.

Freston JW, Malagelada JR, Petersen H, McCloy RF. Critical issues in the management of gastroesophageal reflux disease. Eu J Gastroenterol Hepatol 1995; 7: 577–86.

Fass R, Ofman JJ, Sampliner RE, Camargo L, Wendel C, Fennerty B. The omeprazole test is as sensitive as 24-h oesophageal pH monitoring in diagnosing gastro-oesophageal reflux disease in symptomatic patients with erosive oesophagitis. Aliment Pharmacol Ther 2000; 14: 389–96.

Ivanuša M. Omeprazol in cisaprid za zdravljenje gastroezofagealne refluksne bolezni. Gastroezofagealna refluksna bolezen. Simpozij v sklopu 10. Srečanje internistov in zdravnikov splošne medicine: Iz prakse za prakso. Maribor: Združenje internistov Slovenije, 1999.

Ficko A, Kravanja M, Kristan A, Prodan V, Suhadolc P. Prebivalstvo / Population. Zdravstveni statistični letopis, Slovenija 1999. Zdrav Var 2000; 39: Suppl 1: 3–40.

Dent J, Brun J, Fendrick AM et al. An evidence-based appraisal of reflux disease management – the Genval Workshop Report. Gut 1999; 44: Suppl 2: S1–S16.

Jones RH, Lydeard SE, Hobbs FD et al. Dyspepsia in England and Scotland. Gut 1990; 31: 401–5.

Kennedy T, Jones R. The prevalence of gastro-oesophageal reflux symptoms in a UK population and the consultation behaviour of patients with these symptoms. Aliment Pharmacol Ther 2000; 14: 1589–94.

Westbrook JI, McIntosh J, Talley NJ. Factors associated with consulting medical or non-medical practitioners for dyspepsia: an Australian population-based study. Aliment Pharmacol Ther 2000; 14: 1587–8.

Bianchi Porro G, Pace F. Gastroesophageal reflux in the young and elderly. Motility 1995; 30: 4–6.

Skok P. Vpliv izkoreninjenja bakterije Helicobacter pylori na razvoj refluksne bolezni požiralnika pri bolnikih s krvavečo peptično razjedo. Doktorska disertacija. Ljubljana: Univerza v Ljubljani, Medicinska fakulteta, 2001.

Heading RC. What is the prevalence of gastroesophageal reflux disease and of reflux esophagitis? In: Giuli R, Tytgat GNJ, DeMeester TR, Galmiche JP eds. The esophageal mucosa. Amsterdam: Elsevier; 1994: 62–4.

De Caestecker JS, Bennett JR. The role of endoscopy in gastro-oesophageal reflux disease. In: Lundell L. Guidelines for management of symptomatic gastro-oesophageal reflux disease. London: Science Press 1999: 15–23.

Chiba N, Hunt RH. Gastroesophageal reflux disease. In: McDonald JWD, Burroughs AW, Feagan BG. Evidence based gastroenterology and hepatology. London: BMJ Books, 1999: 16–65.

How to Cite
1.
Pleterski G, Ivanuša M, Drinovec J, Mrhar A. EPIDEMIOLOGICAL ASSESSMENT OF THE PREVALENCE OF GASTROESOPHAGEAL REFLUX DISEASE IN SLOVENIA. TEST ZdravVestn [Internet]. 1 [cited 5Aug.2024];71(6). Available from: http://vestnik-dev.szd.si/index.php/ZdravVest/article/view/1603
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Review

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