Our experiences in preoperative staging of esophageal cancer with endoscopic ultrasound

  • Davorin Ćeranić
  • Bojan Veingerl
  • Pavel Skok
Keywords: esophageal cancer, endoscopic ultrasound, computed tomography, cancer staging, TNM – classification

Abstract

Background: Patients with esophageal cancer have still poor prognosis independent of form of therapy. Endoscopic ultrasonography is an excellent diagnostic tool in staging carcinoma for selecting proper therapeutically approach.

Patients and methods: From January 2002 till June 2005 in 28 patients with oesophageal cancer, endoscopic ultrasound and computed tomography of the chest was performed. The purpose of the study was to compare the assesment of esophageal cancer with surgical and histopathologic findings using TNM classification.

Results: Among our patients, 12 (42.9 %) have been treated surgically and 3 (10.7 %) with radiotherapy or neoadjuvant therapy, one patient (3.6 %) refused surgical treatment. Due to advanced disease or other comorbid conditions 12 patients (42.9 %) could not be treated operatively. For 6 patients (21.5 %) surgical treatment was successful and radical, but for 6 (21.5 %) of them just palliative therapy was possible. In 4 patients (14.3 %) we underestimated T-stage. In 10 patients (35.7 %) oesophagus could not be traversed due to advanced malignant stenosis. Accuracy of endosonography and computed tomography for T-staging was 67 %, for N-staging 67 % for endoscopic ultrasound.

Conclusions: Endosonography is a accurate imaging method for esophageal cancer staging. The results of our analysis have shown that the disease was confirmed in advanced stage in a significant proportion of patients and that malignant stenosis could not be traversed with the conventional endosonographic instrument.

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References

Inoue H. Treatment of esophageal and gastric tumors. Endoscopy 2001; 33: 119–25.

Penman ID, Henry E. Advanced esophageal cancer and endoscopic ultrasound. Gastrointest Endoscopy Clin N Am 2005; 15: 101–16.

United European Gastroenterology Federation. Gastrointestinal cancers in Europe. An extract from the survey the burden of gastroinntestinal disease in Europe being undertaken by public affairs committee, UEGF. Madrid: United European gastroenterology Federation; 2003.

Faivre J, Forman D, Esteve J, Gatta and EUROCARE Working Group. Survival of patients with oesophageal and gastric cancer in Europe. Eur J Cancer 1998; 34: 2167–75.

Newnham A, Quinn MJ, Babb P, Kang JY, Majeed A. Trends in esophageal and gastric cancer incidence, mortality and survival in England and Wales 1971–1998/1999. Aliment Pharmacol Ther 2003;17: 655–64.

Catalano MF, Van Dam J, Sivak MV. Malignant esophageal strictures: staging accuracy of endoscopic ultrasonography. Gastrointest Endosc 1995; 41: 535–9.

Fockens P, Kisman K, Merkus MP, van Lanschot JJB, Obertop H, Tytgat GNJ. The prognosis of esophageal carcinoma staged irresectable (T4) by endosonography. J Am Coll Surg 1998; 186: 17–23.

Van Dam J, Rice TW, Catalano MF, Kirby T, Sivak MV. High-grade malignant stricture of esophageal tumor stage. Risks of endosonographic evaluation.Cancer 1993; 71: 2910–7.

Catalano MF, Sivak MV, Rice T,Gragg LA, Van Dam J. Endosonographic features predictive of lymph node metastasis. Gastrointest Endosc 1994; 40: 442–6.

Chak A, Canto M, Gerdes H, Lightdale CJ, Hawes RH, et al. Prognosis of esophageal cancers preoperatively staged to be locally invasive (T4) by endoscopic ultrasound (EUS): a multicenter retrospective cohort study. Gastrointest Endosc 1995; 42: 501–6.

Hordijk ML, Zander H, van Blankenstein M, Tilanus HW. Influence of tumor stenosis of the accuracy of endosonographic in preoperative T staging of esophageal cancer. Endoscopy 1993; 25: 171–5.

Giovannini M, Monges G, Moutardier V, Bernardini D, Thomas P, et al. Distant lymph node metastases in esophageal cancer: Impact of endoscopic ultrasound-guided biopsy. Endoscopy 1999; 31(7): 36–40.

Wiersema JM, Vilmann P, Giovannini M, Chang KJ, Wiersema LJ. Endosonography-guided fine-needle aspiration biopsy: Diagnostic accuracy and complication assessment. Gastroenterology 1997; 112: 1087–95.

Vazquez-Sequeiros E, Norton ID, Clain JE, Wang KK, Affi A, Allen M, et al. Impact of EUS-guided fine-needle aspiration on lymph node staging in patients with esophageal carcinoma. Gastrointest Endosc 2001; 53: 751–7.

Bhutani MS, Barde CJ, Markert RJ, Gopalswamy N. Length of esophageal cancer and degree of luminal stenosis during upper endoscopy predict T stage by endoscopic ultrasound. Endoscopy 2002; 34(6): 461–3.

Marsman WA, van Wissen M, Bergman JJGHM, van Lanschot JJB, Obertop H, Tytgat GNJ, Fockens P. Outcome of patients with esophageal carcinoma and suspicious celiac lymph nodes as determined by endoscopic ultrasonography. Endoscopy 2004; 36(11): 961–5.

Medical Research Council Oesophageal Cancer Working Party. Surgical resection with or without preoperative chemotherapy in oesophageal cancer: a randomised controlled trial. Lancet 2002; 359: 1727–33.

Greene FL, Page DL, Fleming ID. American Joint Committee on Cancer. TNM classification and stage grouping of esophageal carcinoma. Cancer staging manual. 6th edition. New York: Springer; 2002. p. 91–8.

Walsh TN, Noonan N, Hollywood D, et al. A comparision of multimodal therapy and surgery for esophageal adenocarcinoma. N Engl J Med 1996; 335: 462–7.

Ainsworth AP, Mortensen MB, Durup J, Wamberg PA. Clinical impact of endoscopic ultrasonography at county hospital. Endoscopy 2002; 34(6): 447–50.

Heeren PAM, van Westreen HL, Geersing GJ, van Dullemen HM, Plukker JTM. Influence of tumor characteristics on the accuracy of endoscopic ultrasonography in staging cancer of the esophagus and esophagogastric junction. Endoscopy 2004; 36(11): 966–71.

Romagnuolo J, Scott J, Hawes RH, Hoffman BJ, Reed CE, Guruprasad PA, et al. Helical CT versus EUS with fine needle aspiration for celiac nodal assesment in patients with esophageal cancer. Gastrointest Endosc 2002; 55: 648–54.

Natsugoe S, Mueller J, Stein HJ, Feith M, Hofler H, Siewert JR. Micrometastasis and tumor cell microinvolvement of lymph nodes from esophageal squamous cell carcinoma. Frequency, associated tumor characteristics and impact on prognosis. Cancer 1998; 83: 858–66.

Wallace MB, Hawes RH, Sahai AV, Van Velse A, Hoffman BJ. Dilation of malignant esophageal stenosis to allow EUS guided fine-needle aspiration:safety and effect on patient management. Gastrontest Endosc 2000; 51: 309–13.

Kelly S, Harris KM, Berry E, Hutton J, Roderick P, Cullingworth J, et al. A systemic review of staging performance of endoscopic ultrasound in gastro-oesophageal carcinoma. Gut 2001; 49: 534– 9.

Fockens P, Van den Brande JH, van Dullemen HM, van Lanschott JJ, Tytgat GN. Endosongraphic T-staging of esophageal carcinoma: A learning curve. Gastrointest Endosc 1996; 44: 58–62.

How to Cite
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Ćeranić D, Veingerl B, Skok P. Our experiences in preoperative staging of esophageal cancer with endoscopic ultrasound. TEST ZdravVestn [Internet]. 1 [cited 5Aug.2024];75. Available from: http://vestnik-dev.szd.si/index.php/ZdravVest/article/view/2068
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Professional article