PREGNANCY AND THYROID

  • Simona Gaberšček Klinika za nuklearno medicino Klinični center Zaloška 7 1525 Ljubljana
  • Ksenija Geršak Ginekološka klinika Klinični center Šlajmerjeva 3 1525 Ljubljana
  • Vasilij Matko Cerar Ginekološka klinika Klinični center Šlajmerjeva 3 1525 Ljubljana
  • Sergej Hojker Klinika za nuklearno medicino Klinični center Zaloška 7 1525 Ljubljana
  • Lili Kornhauser Cerar Ginekološka klinika Klinični center Šlajmerjeva 3 1525 Ljubljana
  • Veruška Meglič Matoh Ginekološka klinika Klinični center Šlajmerjeva 3 1525 Ljubljana
  • Helena Molnar Novak Klinika za nuklearno medicino Klinični center Zaloška 7 1525 Ljubljana
  • Živa Novak Antolič Ginekološka klinika Klinični center Šlajmerjeva 3 1525 Ljubljana
  • Edvard Pirnat Klinika za nuklearno medicino Klinični center Zaloška 7 1525 Ljubljana
  • Katja Zaletel Klinika za nuklearno medicino Klinični center Zaloška 7 1525 Ljubljana
Keywords: pregnancy, thyroid gland, thyrotropin (TSH), fetus, hypothyroidism, hyperthyroidism

Abstract

Background. In conditions with appropriate iodine intake, thyroid gland adapts to changes during pregnancy without any consequences. Fetal need for thyroid hormones in the first trimester is directly connected with transplacental transport of thyroid hormones. Fetal synthesis of thyroid hormones depends on availability of iodine in the feto-placental unit. Hypo- and hyperthyroidism during pregnancy are risk factors for pregnant woman and for normal development of fetus and child.

Conclusions. Pregnant women with appropriately treated thyroid diseases have the same outcome of pregnancy as healthy women, and neuroendocrinological development of children is not impaired. If the disease is unrecognized or untreated, complications of pregnancy and delivery occur more frequently. Therefore, timely recognition and treatment of the diseases with appropriate drugs during pregnancy and, also, after delivery is very important.

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References

Zaletel K, Hojker S. Jodni deficit u Sloveniji. In: Tahirović H, Konjhodžić F eds. Simpozijum – jodni deficit u regionu. Sarajevo: Akademija nauka i umjetnosti Bosne i Hercegovine, 2000: 61–9.

Porenta M, Hojker S, Avčin J, Budihna N. Golšavost v Sloveniji. Radiol Oncol 1993; 27: Suppl 6: S46–50.

Zaletel K, Gaberšček S, Hojker S. Obremenitev z jodom in ščitnica. Zdrav Vestn 2000; 69: 449–52.

Pfannenstiel P, Hotze LA, Saller B. Pathophysiologische Grundlagen. In: Pfannenstiel P, Hotze LA, Saller B eds. Schilddrüsenkrankheiten: Diagnose und Therapie. 4. erweiterte und vollständig überarbeitete Aufl. Berlin: Berliner Medizinische Verlagsanstalt, 1999: 19–36.

Gaberšček S, Zaletel K, Hojker S. Fiziologija ščitnice: vloga Na+/I-– simporterja in metabolizem jodida. Zdrav Vestn 2000; 69: 261–5.

Glinoer D. The regulation of thyroid function in pregnancy: pathways of endocrine adaptation from physiology to pathology. Endocr Rev 1997; 18: 404–33.

Moore KL, Persaud TVN. Development of the thyroid gland. In: Moore KL, Persaud TVN eds. The developing human – clinically oriented embryology, 6th ed. Philadelphia: Saunders, 1998: 230–3.

Thorpe-Beeston JG, Nicolaides KH, Felton CV, Butler J, McGregor AM. Maturation of the secretion of thyroid hormone and thyroid-stimulating hormone in the fetus. N Engl J Med 1991; 324: 532–46.

Dowling AL, Martz GU, Leonard JL, Zoeller RT. Acute changes in maternal thyroid hormone induce rapid and transient changes in gene expression in fetal rat brain. Neurosci 2000; 20: 2255–65.

Collins J, Gough S. Autoimmunity in thyroid disease. Eur J Nucl Med 2002; 29: Suppl 2: S417–24.

Weetman AP. Determinants of autoimmune thyroid disease. Nature Immunol 2001; 2: 769–70.

Lazarus JH. Epidemiology and prevention of thyroid disease in pregnancy. Thyroid 2002; 12: 861–5.

Davis LE, Leveno KJ, Cunningham FG. Hypothyroidism complicating pregnancy. Obstet Gynecol 1988; 72: 108–12.

Haddow JE, Palomaki G, Allan WC et al. Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child. N Engl J Med 1999; 341: 549–55.

Azizi F, Hedayati M. Thyroid function in breast-fed infants whose mothers take high doses of methimazole. J Endocrinol Invest 2002; 25: 493–6.

Kriplani A, Buckshee K, Bhargava VL, Takkar D, Ammini AC. Maternal and perinatal outcome in thyrotoxicosis complicating pregnancy. Eur J Obstet Gynecol Reprod Biol 1994; 18: 54: 159–63.

Mestman JH. Hyperthyroidism in pregnancy. Clin Obstet Gynecol 1997; 40: 45–64.

Tan JY, Loh KC, Yeo GS, Chee YC. Transient hyperthyroidism of hyperemesis gravidarum. BJOG 2002; 109: 683–3.

Masiukiewicz US, Burrow GN. Hyperthyroidism in pregnancy: Diagnosis and treatment. Thyroid 1999; 9: 647–52.

Davis LE. Thyroid and Parathyroid Emergencies. In: Clark SL, Cotton DD, Hankins GDV, Phelan JP eds. Critical care obstetrics. 3rd ed. Malden (Massachusetts): Blackwell Science, 1997: 535–50.

Calhoun BC, Brost B. Emergency management of sudden puerperal fever. Endocrinol Metab Clin North Am 1995; 22: 357–67.

Major CA, Nageotte MP. Thyroid disease. In: James DK, Steer PJ, Weiner CP, Gonik B eds. High risk pregnancy. 2nd ed. London: W. B. Saunders, 1999: 709–16.

Zimmerman D. Fetal and neonatal hyperthyroidism. Thyroid 1999; 9: 727– 33.

Glinoer D. Potential consequences of maternal hypothyroidism on the offspring: evidence and implications. Horm Res 2001; 55: 109–14.

Muller AF, Drexhage HA, Berghout A. Postpartum thyroiditis and autoimmune thyroiditis in women of childbearing age: recent insights and consequences for antenatal and postnatal care. Endocr Rev 2001; 22: 605–30.

Amino N, Tada H, Hidaka Y. Postpartum autoimmune thyroid syndrome: a model of aggravation of autoimmune disease. Thyroid 1999; 9: 705–13.

Lazarus JH. Prediction of postpartum thyroiditis. Eur J Endocrinol 1998; 139: 12–3.

How to Cite
1.
Gaberšček S, Geršak K, Cerar VM, Hojker S, Kornhauser Cerar L, Meglič Matoh V, Molnar Novak H, Novak Antolič Živa, Pirnat E, Zaletel K. PREGNANCY AND THYROID. TEST ZdravVestn [Internet]. 1 [cited 5Aug.2024];73(1). Available from: http://vestnik-dev.szd.si/index.php/ZdravVest/article/view/2248
Section
Review

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