HORMONE REPLACEMENT THERAPY AND VENOUS THROMBOEMBOLISM
Abstract
BACKGROUND Oral hormone replacement therapy (HRT) is associated with 2- to 4-fold increased riskof venous thromboembolism (VTE). Therefore, all women commencing HRT should becounselled about the risk of VTE, signs and symptoms of VTE and measures for medicalhelp in the case of VTE suspicion. Absolute risk of VTE is low with around 3 events per 1000users per year. Risk of VTE is probably lower with transdermal then oral HRT, but there areno randomised trials data on this subject. In older women and during the first yearof treatment the risk of VTE is significantly higher. Women with inherited thrombophiliaand those with multiple risk factors for VTE are at particularly high risk. Women with aprevious VTE are at the highest risk of recurrence and HRT should be avoided. CONCLUSIONS Decision for HRT use should be always based on benefit-risk ratio for an individualwomanDownloads
The Author transfers to the Publisher (Zdravniški vestnik/Slovenian Medical Journal) all economic copyrights following form Article 22 of the Slovene Copyright and Related Rights Act (ZASP), including the right of reproduction, the right of distribution, the rental right, the right of public performance, the right of public transmission, the right of public communication by means of phonograms and videograms, the right of public presentation, the right of broadcasting, the right of rebroadcasting, the right of secondary broadcasting, the right of communication to the public, the right of transformation, the right of audiovisual adaptation and all other rights of the author according to ZASP.
The aforementioned rights are transferred non-exclusively, for an unlimited number of editions, for the term of the statutory
The Author can make use of his work himself or transfer subjective rights to others only after 3 months from date of first publishing in the journal Zdravniški vestnik/Slovenian Medical Journal.
The Publisher (Zdravniški vestnik/Slovenian Medical Journal) has the right to transfer the rights, acquired parties without explicit consent of the Author.
The Author consents that the Article be published under the Creative Commons BY-NC 4.0 (attribution-non-commercial) or comparable licence.
